Diver Module

Cancer is a highly heterogeneous disease. Some findings suggest that, although cancer patients exhibit different mutation profiles, driver mutations, and driver genes tend to affect only a limited number of cellular signaling pathways. These mutations do not act alone but usually collaborate through biological pathways or interact within cellular networks. Therefore, the identification of cancer driver modules at the network level, to some extent, can overcome the problem of cancer heterogeneity.

The "Network" page provides driver modules for different cancer types identified by two classical module discovery algorithms (HotNet2 and Hierarchical HotNet). Also, we provide the different interactions of query modules in STRING and MODIG-network.

Example 1 Example 2