TRAIT: T-cell Receptor-Antigen InTeraction database
   

About TRAIT

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TRAIT provides landscape of experimentally verified interactive and non-interactive TCR-antigen pairs, together with multi-dimensional perspectives of interaction features integrating sequences, structures and affinities. The unique features of TRAIT include: i) comprehensive and multi-dimensional information of interactive TCR/antigen pairs including sequences, structures and affinities were collected. ii) The most complete structures of TCR/antigen pairs including 213 experimental validated and 1,575 predicted ones as a supplement are focused on to reveal their interface features. iii) Millions of reliable non-interactive TCR/antigen pairs were uniquely collected, allowing users to query features of amino acids that critical for interaction. iv) 622 mutants of TCRs/antigens were displayed on a separated page to dissect traits of their specific recognition and benefit directed evolution of engineered TCRs.

Overview and Advantages

8036595

TCR-antigen Pairs

1089

Antigen Records

108672

Interactive Pairs

7927923

Non-interactive Pairs

213

Published Structures

1575

Predicted Structures

622

Mutation Records

290

Publications
                     

Sequences     Structures       Affinities

  • Comprehensive integration of sequences, structures and affinities;
  • Multi-dimensional perspectives of interaction features;
  • Landscape of experimentally verified TCR-antigen pairs;
  • Unique platform for non-interactive TCR-antigen pairs.
 

Mutations  & Evolution

  • Systematic display of mutation-affinity data for TCR-antigen pairs.
  • Useful platform for the affinity maturation of engineered TCRs;
  • Conducive to De novo design of TCRs;
  • Powerful source for immunotherapies and vaccine design.

Statistics

General Records

Record statistics by year

Line chart of unique TCR-antigen pairs, epitopes, MHC alleles and published structures cumulated by year. Data used for visualization are computed using interactive TCR-antigen pairs in the search page.

Summary of TCR records and V(D)J usage

TCR sequence length distrubution

Average V-J gene utilization of paired TCR sequences

Representative data for interactive pairs, only variable genes with at least 45 records(α chain)/60 records(β chain) are shown.

Average V-J gene utilization of α chain

Average V-J gene utilization of β chain

Summary by antigens

 
 

Detailed summary data of epitopes.

 
Epitope speciesUnique Epitopes for paired TCRsUnique Epitopes for
un-paired TCRs
Interactive paired TCRsInteractive unpaired TCRsNon-interactive
TCRs
InfluenzaA81324106983151171
Homo sapiens1664895330941440145
EBV2713475217171887219
CMV14291473085591408426
SARS-CoV-2574339270618270
HIV125391483044800204
M.tuberculosis1113040
Pseudomonas Aeruginosa10100
Pseudomonas Fluorescens10100
HSV-2117540
Triticum Aestivum9113250
Selaginella Moellendorffii10100
synthetic3003400
HCV13147987530
HHV10100
DENV3/41141660
DENV11241690
YFV112472850
E.Coli20200
HTLV-17146135160011
HPV10140320104
Streptomyces Kanamyceticus10300
Saccharomyces Cerevisiae10100
MCPyV20600
HCoV-HKU1112490
DENV2010600
Total90050527004268346167280
 

Detailed summary data of MHC alleles (Records >50).

MHC AMHC BMHC classInteractive paired
TCRs
Interactive unpaired TCRsTotal
HLA-A*02B2MMHCI4671444914916
HLA-A*03:01B2MMHCI1442410314527
HLA-A*02:01B2MMHCI5834424810082
HLA-A*01B2MMHCI042484248
HLA-A*11:01B2MMHCI24884382926
HLA-B*08:01B2MMHCI12744021676
HLA-B*07:02B2MMHCI6609451605
HLA-A*01:01B2MMHCI7905941384
HLA-DRA*01:01HLA-DRB1*11:01MHCII0726726
HLA-DRA*01HLA-DRB1*11:01MHCII0726726
HLA-B*08B2MMHCI40560600
HLA-B*57:01B2MMHCI193346539
HLA-B*27B2MMHCI0494494
HLA-A*24:02B2MMHCI276194470
HLA-B*44B2MMHCI0418418
HLA-B*08:01B2MMHCI0402402
HLA-B*27:05B2MMHCI0370370
HLA-B*57:01B2MMHCI0346346
HLA-B*42:01B2MMHCI8336344
HLA-DRA1*01HLA-DRB1*15MHCII0338338
HLA-B*57B2MMHCI0244244
HLA-B*35:01B2MMHCI23208231
HLA-B*44:03:08B2MMHCI0183183
HLA-A*68:01B2MMHCI11333146
HLA-DRA*01HLA-DRB1*07:01MHCII1110111
HLA-DRA*01:01HLA-DRB1*07:01MHCII1090109
HLA-B*15:01B2MMHCI1021103
HLA-A*02:01:48B2MMHCI86086
HLA-A*08:01B2MMHCI65974
HLA-B*35:08B2MMHCI184058
HLA-A*03B2MMHCI05555
     

Correspondence between TCRs and antigens

Zoom-in for correspondence between epitope genes, epitope, MHC and TCR chains (links supported by more than 100 records).

Correspondence between TRBV genes and MHC class I alleles.

Gene

HLA

Epitope

TCR Chain

Alluvium plot of epitopes grouped by Gene, HLA and TCR.