About TRAIT
TRAIT provides landscape of experimentally verified interactive and non-interactive TCR-antigen pairs, together with multi-dimensional perspectives of interaction features integrating sequences, structures and affinities. The unique features of TRAIT include: i) comprehensive and multi-dimensional information of interactive TCR/antigen pairs including sequences, structures and affinities were collected. ii) The most complete structures of TCR/antigen pairs including 213 experimental validated and 1,575 predicted ones as a supplement are focused on to reveal their interface features. iii) Millions of reliable non-interactive TCR/antigen pairs were uniquely collected, allowing users to query features of amino acids that critical for interaction. iv) 622 mutants of TCRs/antigens were displayed on a separated page to dissect traits of their specific recognition and benefit directed evolution of engineered TCRs.
Overview and Advantages
8036595
TCR-antigen Pairs
1089
Antigen Records
108672
Interactive Pairs
7927923
Non-interactive Pairs
213
Published Structures
1575
Predicted Structures
622
Mutation Records
290
Publications
Sequences Structures Affinities
- Comprehensive integration of sequences, structures and affinities;
- Multi-dimensional perspectives of interaction features;
- Landscape of experimentally verified TCR-antigen pairs;
- Unique platform for non-interactive TCR-antigen pairs.
Mutations & Evolution
- Systematic display of mutation-affinity data for TCR-antigen pairs.
- Useful platform for the affinity maturation of engineered TCRs;
- Conducive to De novo design of TCRs;
- Powerful source for immunotherapies and vaccine design.
Statistics
General Records
Record statistics by year
Line chart of unique TCR-antigen pairs, epitopes, MHC alleles and published structures cumulated by year. Data used for visualization are computed using interactive TCR-antigen pairs in the search page.
Summary of TCR records and V(D)J usage
TCR sequence length distrubution
Average V-J gene utilization of paired TCR sequences
Representative data for interactive pairs, only variable genes with at least 45 records(α chain)/60 records(β chain) are shown.
Average V-J gene utilization of α chain
Average V-J gene utilization of β chain
Summary by antigens
Detailed summary data of epitopes.
| Epitope species | Unique Epitopes for paired TCRs | Unique Epitopes for un-paired TCRs | Interactive paired TCRs | Interactive unpaired TCRs | Non-interactive TCRs |
| InfluenzaA | 8 | 13 | 2410 | 6983 | 151171 |
| Homo sapiens | 166 | 48 | 953 | 3094 | 1440145 |
| EBV | 27 | 13 | 4752 | 1717 | 1887219 |
| CMV | 14 | 29 | 14730 | 8559 | 1408426 |
| SARS-CoV-2 | 574 | 339 | 2706 | 1827 | 0 |
| HIV1 | 25 | 39 | 148 | 3044 | 800204 |
| M.tuberculosis | 11 | 1 | 30 | 4 | 0 |
| Pseudomonas Aeruginosa | 1 | 0 | 1 | 0 | 0 |
| Pseudomonas Fluorescens | 1 | 0 | 1 | 0 | 0 |
| HSV-2 | 1 | 1 | 75 | 4 | 0 |
| Triticum Aestivum | 9 | 1 | 13 | 25 | 0 |
| Selaginella Moellendorffii | 1 | 0 | 1 | 0 | 0 |
| synthetic | 30 | 0 | 34 | 0 | 0 |
| HCV | 13 | 14 | 798 | 753 | 0 |
| HHV | 1 | 0 | 1 | 0 | 0 |
| DENV3/4 | 1 | 1 | 4 | 166 | 0 |
| DENV1 | 1 | 2 | 4 | 169 | 0 |
| YFV | 1 | 1 | 247 | 285 | 0 |
| E.Coli | 2 | 0 | 2 | 0 | 0 |
| HTLV-1 | 7 | 1 | 46 | 135 | 160011 |
| HPV | 1 | 0 | 14 | 0 | 320104 |
| Streptomyces Kanamyceticus | 1 | 0 | 3 | 0 | 0 |
| Saccharomyces Cerevisiae | 1 | 0 | 1 | 0 | 0 |
| MCPyV | 2 | 0 | 6 | 0 | 0 |
| HCoV-HKU1 | 1 | 1 | 24 | 9 | 0 |
| DENV2 | 0 | 1 | 0 | 60 | 0 |
| Total | 900 | 505 | 27004 | 26834 | 6167280 |
Detailed summary data of MHC alleles (Records >50).
| MHC A | MHC B | MHC class | Interactive paired TCRs | Interactive unpaired TCRs | Total |
| HLA-A*02 | B2M | MHCI | 467 | 14449 | 14916 |
| HLA-A*03:01 | B2M | MHCI | 14424 | 103 | 14527 |
| HLA-A*02:01 | B2M | MHCI | 5834 | 4248 | 10082 |
| HLA-A*01 | B2M | MHCI | 0 | 4248 | 4248 |
| HLA-A*11:01 | B2M | MHCI | 2488 | 438 | 2926 |
| HLA-B*08:01 | B2M | MHCI | 1274 | 402 | 1676 |
| HLA-B*07:02 | B2M | MHCI | 660 | 945 | 1605 |
| HLA-A*01:01 | B2M | MHCI | 790 | 594 | 1384 |
| HLA-DRA*01:01 | HLA-DRB1*11:01 | MHCII | 0 | 726 | 726 |
| HLA-DRA*01 | HLA-DRB1*11:01 | MHCII | 0 | 726 | 726 |
| HLA-B*08 | B2M | MHCI | 40 | 560 | 600 |
| HLA-B*57:01 | B2M | MHCI | 193 | 346 | 539 |
| HLA-B*27 | B2M | MHCI | 0 | 494 | 494 |
| HLA-A*24:02 | B2M | MHCI | 276 | 194 | 470 |
| HLA-B*44 | B2M | MHCI | 0 | 418 | 418 |
| HLA-B*08:01 | B2M | MHCI | 0 | 402 | 402 |
| HLA-B*27:05 | B2M | MHCI | 0 | 370 | 370 |
| HLA-B*57:01 | B2M | MHCI | 0 | 346 | 346 |
| HLA-B*42:01 | B2M | MHCI | 8 | 336 | 344 |
| HLA-DRA1*01 | HLA-DRB1*15 | MHCII | 0 | 338 | 338 |
| HLA-B*57 | B2M | MHCI | 0 | 244 | 244 |
| HLA-B*35:01 | B2M | MHCI | 23 | 208 | 231 |
| HLA-B*44:03:08 | B2M | MHCI | 0 | 183 | 183 |
| HLA-A*68:01 | B2M | MHCI | 113 | 33 | 146 |
| HLA-DRA*01 | HLA-DRB1*07:01 | MHCII | 111 | 0 | 111 |
| HLA-DRA*01:01 | HLA-DRB1*07:01 | MHCII | 109 | 0 | 109 |
| HLA-B*15:01 | B2M | MHCI | 102 | 1 | 103 |
| HLA-A*02:01:48 | B2M | MHCI | 86 | 0 | 86 |
| HLA-A*08:01 | B2M | MHCI | 65 | 9 | 74 |
| HLA-B*35:08 | B2M | MHCI | 18 | 40 | 58 |
| HLA-A*03 | B2M | MHCI | 0 | 55 | 55 |
Correspondence between TCRs and antigens
Zoom-in for correspondence between epitope genes, epitope, MHC and TCR chains (links supported by more than 100 records).
Correspondence between TRBV genes and MHC class I alleles.
Gene
HLA
Epitope
TCR Chain
Alluvium plot of epitopes grouped by Gene, HLA and TCR.