Overview

CovEpiAb is a curated database and analysis resource for human coronaviruses (HCoVs) immune epitopes and antibodies. It includes 66 210 experimentally validated B-cell epitopes and 3209 T-cell epitopes, 5304 antibodies with interaction profiles, virological data on 16 SARS-CoV-2 variants, and efficacy results from 57 vaccines, 38 antibodies, and 13 convalescent plasma samples. Also offers epitope prediction and analysis through COVEP pipeline for identifying conserved epitopes. CovEpiAb serves as a valuable resource that would be benefit for the development of effective broad-spectrum vaccines and neutralizing antibodies against HCoVs.

66210

Validated B epitopes

3209

Validated T epitopes

5304

Antibodies

538

Antibody structures

1291

Affinity Records

4969

Neutralizing Records

6850

Therapeutic Records

237401

Predicted T epitopes

Records with information extracted from literature and computational analysis

News & Events

Framework

Features

  • Curating immune epitopes and integrating an epitope prediction pipeline (COVEP) to facilitate the identification of conserved cross-reactive epitopes for broad-spectrum vaccine development.

  • Providing refined antibody annotation, enabling the analysis of binding and neutralization profiles against HCoVs and aiding in the identification of potential therapeutic targets.

  • Offering virological characteristics of SARS-CoV-2 VOCs and efficacy data for therapeutics, allowing researchers to assess the impact of emerging variants on existing vaccines and treatments.