CovEpiAb

Overview

CovEpiAb is a curated database and analysis resource for human coronaviruses (HCoVs) immune epitopes and antibodies. It includes 66 210 experimentally validated B-cell epitopes and 3209 T-cell epitopes, 5304 antibodies with interaction profiles, virological data on 16 SARS-CoV-2 variants, and efficacy results from 57 vaccines, 38 antibodies, and 13 convalescent plasma samples. Also offers epitope prediction and analysis through COVEP pipeline for identifying conserved epitopes. CovEpiAb serves as a valuable resource that would be benefit for the development of effective broad-spectrum vaccines and neutralizing antibodies against HCoVs.

Epitope Antibody Variants COVEP Help

66210

Validated B epitopes

3209

Validated T epitopes

5304

Antibodies

538

Antibody structures

1291

Affinity Records

4969

Neutralizing Records

6850

Therapeutic Records

237401

Predicted T epitopes

Records with information extracted from literature and computational analysis

News & Events

2023.07.13
Add the News & Events section.
2023.05
Refine the help content.
2023.04
Add data description for scatterplot in variant and therapeutic detailed page.
2023.04
Update the instructions for using the COVEP pipeline.
2023.02
Add epitope experimental assays and antibody network tree diagram in item detailed page.
2023.01
Provides links to data downloads.
2022.11
Start database building, adding epitopes, antibodies and SARS-CoV-2 variants data.

Framework

Features

Curating immune epitopes and integrating an epitope prediction pipeline (COVEP) to facilitate the identification of conserved cross-reactive epitopes for broad-spectrum vaccine development.

Providing refined antibody annotation, enabling the analysis of binding and neutralization profiles against HCoVs and aiding in the identification of potential therapeutic targets.

Offering virological characteristics of SARS-CoV-2 VOCs and efficacy data for therapeutics, allowing researchers to assess the impact of emerging variants on existing vaccines and treatments.