PIK3CA N345K

Level: Level 1A

OncoKB™: Oncogenic Gain-of-function
FASMIC: Activating
ClinVar: Pathogenic
Description

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Overview
  • Mutation PIK3CA N345K
  • Chromosome 3
  • Position 178921553
  • Ensembl ID ENSG00000121879
  • Select Transcript ENST00000263967:c.1035T>A;c.1035T>G
Related Link
Effect scores
    SIFT T SIFT4G T Polyphen2-HDIV D Polyphen2-HVAR D LRT D MutationTaster N
    MutationAssessor M PROVEAN D VEST4 D MetaSVM T MetaLR T MetaRNN D
    M-CAP D REVEL D MutPred D MVP D MPC D PrimateAI D
    DEOGEN2 D BayesDel_addAF T BayesDel_noAF T ClinPred D LIST-S2 D CADD_hg19 D
    DANN D fathmm-MKL D fathmm-XF N Eigen N Eigen-PC N GenoCanyon N
  • SIFT, SIFT4G, Polyphen2-HVAR, MetaSVM, MetaLR, MetaRNN, M-CAP, MVP, MPC, PrimateAI,BayesDel_addAF, BayesDel_noAF, ClinPred, LIST-S2:
    • D(amaging); T(olerated)
  • Polyphen2-HDIV:
    • D(amaging); P(ossibly damaging); B(enign)
  • LRT:
    • D(eleterious); N(eutral); U(nknown)
  • MutationTaster, PROVEAN, VEST4, REVEL, MutPred, DEOGEN2, CADD_hg19, DANN, fathmm-MKL coding, fathmm-XF coding, Eigen, Eigen-PC, GenoCanyon:
    • D(amaging); N(eutral)
  • MutationAssessor:
    • H(igh); M(edium); L(ow); N(eutral)
TCGA
ICGC

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Correspondence

Lab of Pharmacogenomics, College of Pharmaceutical Sciences, Zhejiang University, China

Cite

Zhao W, Yang J, Wu J, et al. CanDriS: posterior profiling of cancer-driving sites based on two-component evolutionary model. Brief Bioinform 2021;22(5):bbab131.
Zhao W, Gu X, Chen S, et al. MODIG: integrating multi-omics and multi-dimensional gene network for cancer driver gene identification based on graph attention network model. Bioinformatics 2022;38(21):4901-7.

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