Ensembl ID | ENSG00000141510

Transcript ID | ENST00000269305

CDS length | 1182

NCBI | 7157

HGNC Id | 11998

Refseq ID | NM_000546

Uniprot ID | P04637

UCSC ID | uc060aur.1

OMIM ID | 191170

CIViC ID | 45

OncoKB |

Pharos |

Gene position | 17:7565097-7590856

Cytoband | 17p13.1

Gene Type | protein-coding gene

Protein family | P53 family

Pathway(KEGG) | Amyotrophic lateral sclerosis, Apoptosis, Basal cell carcinoma, Bladder cancer, Breast cancer, Cell cycle, Cellular senescence, Central carbon metabolism in cancer, Chromosome and associated proteins, Chronic myeloid leukemia, Colorectal cancer, DNA repair and recombination proteins, Endocrine resistance, Endometrial cancer, Epstein-Barr virus infection, Ferroptosis, Fluid shear stress and atherosclerosis, Gastric cancer, Glioma, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Huntington disease, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Longevity regulating pathway, MAPK signaling pathway, Measles, Melanoma, MicroRNAs in cancer, Mitophagy - animal, Neurotrophin signaling pathway, Non-small cell lung cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parkinson disease, Pathways in cancer, Platinum drug resistance, Prostate cancer, Proteoglycans in cancer, Shigellosis, Small cell lung cancer, Sphingolipid signaling pathway, Thyroid cancer, Thyroid hormone signaling pathway, Transcription factors, Transcriptional misregulation in cancer, Viral carcinogenesis, Wnt signaling pathway, p53 signaling pathway,

Pathway(Signor) | Pentose phosphate pathway, Mitochondrial Control of Apoptosis, P38 Signaling, Non-small-cell lung cancer (NSCLC), Prostate Cancer, Luminal Breast Cancer, Acute Myeloid Leukemia, Cell cycle: G2/M phase transition, Colorectal Carcinoma, Glycolysis and Gluconeogenesis, EBV infection, Cell cycle: G1/S phase transition, Pancreatic ductal adenocarcinoma (PDA), Malignant Melanoma,

Pathway(Rectome) | Activation of BH3-only proteins, Activation of NOXA and translocation to mitochondria, Activation of PUMA and translocation to mitochondria, Antiviral mechanism by IFN-stimulated genes, Apoptosis, Association of TriC/CCT with target proteins during biosynthesis, Autodegradation of the E3 ubiquitin ligase COP1, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chaperonin-mediated protein folding, Cytokine Signaling in Immune system, DNA Damage/Telomere Stress Induced Senescence, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Defective Intrinsic Pathway for Apoptosis, Deubiquitination, Developmental Biology, Disease, Diseases of programmed cell death, Diseases of signal transduction by growth factor receptors and second messengers, Factors involved in megakaryocyte development and platelet production, Formation of Senescence-Associated Heterochromatin Foci (SAHF), G1/S DNA Damage Checkpoints, G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, Hemostasis, Immune System, Innate Immune System, Interferon Signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-4 and Interleukin-13 signaling, Intracellular signaling by second messengers, Intrinsic Pathway for Apoptosis, Loss of Function of TP53 in Cancer, Loss of function of TP53 in cancer due to loss of tetramerization ability, Maternal to zygotic transition (MZT), Metabolism of proteins, Mitotic G2-G2/M phases, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Oncogene Induced Senescence, Ovarian tumor domain proteases, Oxidative Stress Induced Senescence, PI5P Regulates TP53 Acetylation, PIP3 activates AKT signaling, PKR-mediated signaling, PTEN Regulation, Post-translational protein modification, Pre-NOTCH Expression and Processing, Pre-NOTCH Transcription and Translation, Programmed Cell Death, Protein folding, Pyroptosis, RNA Polymerase II Transcription, RUNX3 regulates CDKN1A transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulated Necrosis, Regulation of NF-kappa B signaling, Regulation of PTEN gene transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Regulation of TP53 Activity through Association with Co-factors, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression, Regulation of TP53 Expression and Degradation, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription factors, Signal Transduction, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by Interleukins, Signaling by NOTCH, Stabilization of p53, TAK1-dependent IKK and NF-kappa-B activation, TP53 Regulates Metabolic Genes, TP53 Regulates Transcription of Caspase Activators and Caspases, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of DNA Repair Genes, TP53 Regulates Transcription of Death Receptors and Ligands, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling, The role of GTSE1 in G2/M progression after G2 checkpoint, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcriptional activation of cell cycle inhibitor p21, Transcriptional Regulation by TP53, Transcriptional Regulation by VENTX, Transcriptional activation of p53 responsive genes, Transcriptional regulation by RUNX3, Ub-specific processing proteases, Zygotic genome activation (ZGA), p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint,

Pathway(Uniprot) | /