Help – TRAIT: T-cell Receptor-Antigen InTeraction database
               

Glossary

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Term Definition
TCR T cell receptor.
Antigen Peptide-major histocompatibility complex multimer which can be recognized by TCR.
MHC The major histocompatibility complex.
HLA The human leukocyte antigen.
CDR3 α/β The third complementarity determining region of the T-cell receptor(TCR) α and β chains.
TRAV/TRAJ V/J gene of TCR α chain.
TRBV/TRBJ V/J gene of TCR β chain.
Peptide_species Species of peptide.
HLA_mut/Pep_mut/TCR_mut The mutant site of HLA/peptide/TCR.
Binding Descript the binding capacity between TCR and pMHC. TRUE (Binding); FALSE(Non-Binding).
Affinity The binding affinity between TCR and pMHC.
Structure The structure of TCR-pMHC complexes from PDB.
Interactive pairs The pairs of TCR and antigen that can interact with each other.
Non-interactive pairs The pairs of TCR and antigen that can not interact with each other.

Usage of TRAIT

TRAIT provides a landscape of experimentally verified interactive and non-interactive TCR-antigen pairs, together with multi-dimensional perspectives of interaction features integrating sequences, structures, and affinities. TRAIT is dedicated to providing users with relevant data from “discovery, optimization, and clinical evaluations” TCRs, facilitating the development of T cell-based immunotherapies.  Some images on the webpage were created with BioRender.com. The main sections of this website are Home, Search, Omics, Mutations, Therapeutics, Download and Help.

About Us

  Citation

Mengmeng Wei, Jingcheng Wu, Shengzuo Bai, Yuxuan Zhou, Yichang Chen, Xue Zhang, Wenyi Zhao, Ying Chi, Gang Pan, Feng Zhu, Shuqing Chen, Zhan Zhou, TRAIT: A Comprehensive Database for T-cell Receptor–Antigen Interactions, Genomics, Proteomics & Bioinformatics, 2025, qzaf033, https://doi.org/10.1093/gpbjnl/qzaf033

  Contact

If you have any questions and helpful suggestions, please contact us.
E-mail: zhanzhou@zju.edu.cn
Address: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Updating

  Latest Updates

1. TRAIT was last updated on March 16, 2025.
2. Affinity data has been updated on both the Search and Mutations pages.
   

Cite TRAIT

Mengmeng Wei, Jingcheng Wu, Shengzuo Bai, Yuxuan Zhou, Yichang Chen, Xue Zhang, Wenyi Zhao, Ying Chi, Gang Pan, Feng Zhu, Shuqing Chen, Zhan Zhou, TRAIT: A Comprehensive Database for T-cell Receptor–Antigen Interactions, Genomics, Proteomics & Bioinformatics, 2025, qzaf033, https://doi.org/10.1093/gpbjnl/qzaf033

About TRAIT

TRAIT is a comprehensive database of T cell receptor antigen interaction with the aim to provide a versatile landscape of T cell receptor recognition of antigens. (Last updated on 30th October, 2024)

Glabal Visitors

Correspondence

College of Pharmaceutical Sciences,
Zhejiang University, China

College of Computer Science and Technology,
Zhejiang University, China

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