Glossary
Term | Definition |
---|---|
TCR | T cell receptor. |
Antigen | Peptide-major histocompatibility complex multimer which can be recognized by TCR. |
MHC | The major histocompatibility complex. |
HLA | The human leukocyte antigen. |
CDR3 α/β | The third complementarity determining region of the T-cell receptor(TCR) α and β chains. |
TRAV/TRAJ | V/J gene of TCR α chain. |
TRBV/TRBJ | V/J gene of TCR β chain. |
Peptide_species | Species of peptide. |
HLA_mut/Pep_mut/TCR_mut | The mutant site of HLA/peptide/TCR. |
Binding | Descript the binding capacity between TCR and pMHC. TRUE (Binding); FALSE(Non-Binding). |
Affinity | The binding affinity between TCR and pMHC. |
Structure | The structure of TCR-pMHC complexes from PDB. |
Interactive pairs | The pairs of TCR and antigen that can interact with each other. |
Non-interactive pairs | The pairs of TCR and antigen that can not interact with each other. |
Usage of TRAIT
TRAIT provides a landscape of experimentally verified interactive and non-interactive TCR-antigen pairs, together with multi-dimensional perspectives of interaction features integrating sequences, structures, and affinities. TRAIT is dedicated to providing users with relevant data from “discovery, optimization, and clinical evaluations” TCRs, facilitating the development of T cell-based immunotherapies. Some images on the webpage were created with BioRender.com. The main sections of this website are Home, Search, Omics, Mutations, Therapeutics, Download and Help.
About Us
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Contact
If you have any questions and helpful suggestions, please contact us.
E-mail: zhanzhou@zju.edu.cn
Address: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Address: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.