Help – TRAIT: T-cell Receptor-Antigen InTeraction database
               

Glossary

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Term Definition
TCR T cell receptor.
Antigen Peptide-major histocompatibility complex multimer which can be recognized by TCR.
MHC The major histocompatibility complex.
HLA The human leukocyte antigen.
CDR3 α/β The third complementarity determining region of the T-cell receptor(TCR) α and β chains.
TRAV/TRAJ V/J gene of TCR α chain.
TRBV/TRBJ V/J gene of TCR β chain.
Peptide_species Species of peptide.
HLA_mut/Pep_mut/TCR_mut The mutant site of HLA/peptide/TCR.
Binding Descript the binding capacity between TCR and pMHC. TRUE (Binding); FALSE(Non-Binding).
Affinity The binding affinity between TCR and pMHC.
Structure The structure of TCR-pMHC complexes from PDB.
Interactive pairs The pairs of TCR and antigen that can interact with each other.
Non-interactive pairs The pairs of TCR and antigen that can not interact with each other.

Usage of TRAIT

TRAIT provides a landscape of experimentally verified interactive and non-interactive TCR-antigen pairs, together with multi-dimensional perspectives of interaction features integrating sequences, structures, and affinities. TRAIT is dedicated to providing users with relevant data from “discovery, optimization, and clinical evaluations” TCRs, facilitating the development of T cell-based immunotherapies.  Some images on the webpage were created with BioRender.com. The main sections of this website are Home, Search, Omics, Mutations, Therapeutics, Download and Help.

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E-mail: zhanzhou@zju.edu.cn
Address: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.