About TRAIT
TRAIT provides landscape of experimentally verified interactive and non-interactive TCR-antigen pairs, together with multi-dimensional perspectives of interaction features integrating sequences, structures and affinities. The unique features of TRAIT include: i) comprehensive and multi-dimensional information of interactive TCR/antigen pairs including sequences, structures and affinities were collected. ii) The most complete structures of TCR/antigen pairs including 213 experimental validated and 1,575 predicted ones as a supplement are focused on to reveal their interface features. iii) Millions of reliable non-interactive TCR/antigen pairs were uniquely collected, allowing users to query features of amino acids that critical for interaction. iv) 622 mutants of TCRs/antigens were displayed on a separated page to dissect traits of their specific recognition and benefit directed evolution of engineered TCRs.
Overview and Advantages
8,036,841
TCR-antigen Pairs
1,191
Antigen Records
108,918
Interactive Pairs
7,927,923
Non-interactive Pairs
226
Published Structures
711
Mutation Records
336
Publications
34
Clinical trails
Sequences Structures Affinities
- Comprehensive integration of sequences, structures and affinities;
- Multi-dimensional perspectives of interaction features;
- Landscape of experimentally verified TCR-antigen pairs;
- Unique platform for non-interactive TCR-antigen pairs.
Mutations & Evolution
- Systematic display of mutation-affinity data for TCR-antigen pairs.
- Useful platform for the affinity maturation of engineered TCRs;
- Conducive to De novo design of TCRs;
- Powerful source for immunotherapies and vaccine design.
Statistics
General Records
Record statistics by year
Line chart of unique TCR-antigen pairs, epitopes, MHC alleles and published structures cumulated by year. Data used for visualization are computed using interactive TCR-antigen pairs in the search page.
Summary of TCR records and V(D)J usage
TCR sequence length distrubution
Average V-J gene utilization of paired TCR sequences
Representative data for interactive pairs, only variable genes with at least 45 records(α chain)/60 records(β chain) are shown.
Average V-J gene utilization of α chain
Average V-J gene utilization of β chain
Summary by antigens
Detailed summary data of epitopes.
| Epitope species | Unique Epitopes for paired TCRs | Unique Epitopes for un-paired TCRs | Interactive paired TCRs | Interactive unpaired TCRs | Non-interactive TCRs |
| Bacteroides Fragilis | 1 | 0 | 1 | 0 | 0 |
| CMV | 13 | 29 | 32,787 | 8,569 | 1,408,426 |
| DENV1 | 1 | 1 | 4 | 169 | 0 |
| DENV2 | 0 | 1 | 0 | 60 | 0 |
| DENV3/4 | 1 | 1 | 4 | 166 | 0 |
| E.Coli | 2 | 0 | 2 | 0 | 0 |
| EBV | 28 | 13 | 33,849 | 1,717 | 1,887,219 |
| Enterocloster Asparagiformis | 1 | 0 | 1 | 0 | 0 |
| HCoV-229E | 1 | 0 | 1 | 0 | 0 |
| HCoV-HKU1 | 3 | 1 | 26 | 9 | 0 |
| HCoV-NL63 | 1 | 0 | 1 | 0 | 0 |
| HCoV-OC43 | 2 | 0 | 2 | 0 | 0 |
| HCV | 13 | 14 | 798 | 753 | 0 |
| HHV | 1 | 0 | 1 | 0 | 0 |
| HIV | 25 | 39 | 141 | 3,200 | 800,204 |
| Homo Sapiens | 232 | 54 | 1,161 | 3,109 | 1,600,192 |
| HPV | 1 | 0 | 12 | 0 | 320,103 |
| HSV-2 | 1 | 1 | 75 | 4 | 0 |
| HTLV-1 | 7 | 1 | 61 | 135 | 160,011 |
| InfluenzaA | 10 | 13 | 9,957 | 6,983 | 151,171 |
| M.tuberculosis | 11 | 1 | 30 | 4 | 0 |
| MCPyV | 2 | 0 | 6 | 0 | 0 |
| MERS-Cov | 3 | 0 | 4 | 0 | 0 |
| NA | 1 | 0 | 1 | 0 | 0 |
| PAR1 | 1 | 0 | 2 | 0 | 0 |
| Pseudomonas Aeruginosa | 1 | 0 | 1 | 0 | 0 |
| Pseudomonas Fluorescens | 1 | 0 | 1 | 0 | 0 |
| Saccharomyces Cerevisiae | 1 | 0 | 1 | 0 | 0 |
| SARS-CoV-2 | 575 | 339 | 2,712 | 1,827 | 0 |
| Selaginella Moellendorffii | 1 | 0 | 1 | 0 | 0 |
| synthetic | 26 | 0 | 30 | 0 | 0 |
| Triticum Aestivum | 9 | 1 | 13 | 25 | 0 |
| YFV | 1 | 1 | 247 | 285 | 0 |
| Total | 977 | 510 | 81,933 | 27,015 | 6,327,326 |
Detailed summary data of MHC alleles (Records >50).
| MHC A | MHC B | MHC class | Interactive paired TCRs | Interactive unpaired TCRs | Total |
| HLA-A*01 | B2M | MHCI | 0 | 66 | 66 |
| HLA-A*01:01 | B2M | MHCI | 812 | 1,406 | 2,218 |
| HLA-A*02 | B2M | MHCI | 173 | 14,422 | 14,595 |
| HLA-A*02:01 | B2M | MHCI | 15,175 | 19,433 | 34,608 |
| HLA-A*02:01:48 | B2M | MHCI | 86 | 86 | 172 |
| HLA-A*03 | B2M | MHCI | 0 | 55 | 55 |
| HLA-A*03:01 | B2M | MHCI | 32,543 | 32,646 | 65,189 |
| HLA-A*08:01 | B2M | MHCI | 65 | 74 | 139 |
| HLA-A*11:01 | B2M | MHCI | 11,033 | 11,471 | 22,504 |
| HLA-A*24:02 | B2M | MHCI | 264 | 458 | 722 |
| HLA-A*68:01 | B2M | MHCI | 118 | 151 | 269 |
| HLA-B*07:02 | B2M | MHCI | 659 | 1,604 | 2,263 |
| HLA-B*08 | B2M | MHCI | 22 | 359 | 381 |
| HLA-B*08:01 | B2M | MHCI | 20,023 | 20,425 | 40,448 |
| HLA-B*15:01 | B2M | MHCI | 102 | 103 | 205 |
| HLA-B*27 | B2M | MHCI | 0 | 494 | 494 |
| HLA-B*27:05 | B2M | MHCI | 4 | 374 | 378 |
| HLA-B*35:01 | B2M | MHCI | 23 | 231 | 254 |
| HLA-B*35:08 | B2M | MHCI | 18 | 58 | 76 |
| HLA-B*42:01 | B2M | MHCI | 1 | 337 | 338 |
| HLA-B*44 | B2M | MHCI | 0 | 418 | 418 |
| HLA-B*44:03:08 | B2M | MHCI | 0 | 183 | 183 |
| HLA-B*57 | B2M | MHCI | 0 | 244 | 244 |
| HLA-B*57:01 | B2M | MHCI | 193 | 539 | 732 |
| HLA-DRA*01 | HLA-DRB1*01 | MHCII | 0 | 1,174 | 1,174 |
| HLA-DRA*01 | HLA-DRB1*07:01 | MHCII | 0 | 55 | 55 |
| HLA-DRA*01 | HLA-DRB5*01:01 | MHCII | 0 | 64 | 64 |
| HLA-DRA*01:01 | HLA-DRB1*01:01 | MHCII | 0 | 58 | 58 |
| HLA-DRA*01:01 | HLA-DRB1*04:01 | MHCII | 77 | 209 | 286 |
| HLA-DRA*01:01 | HLA-DRB1*11:01 | MHCII | 2 | 155 | 157 |
| HLA-DRA*01:01 | HLA-DRB1*15:01 | MHCII | 0 | 107 | 107 |
| HLA-DRA*01:01 | HLA-DRB5*01:01 | MHCII | 2 | 257 | 259 |
| HLA-DRA1*01 | HLA-DRB1*15 | MHCII | 0 | 308 | 308 |
Correspondence between TCRs and antigens
Zoom-in for correspondence between epitope genes, epitope, MHC and TCR chains (links supported by more than 100 records).
Correspondence between TRBV genes and MHC class I alleles.
Gene
HLA
Epitope
TCR Chain
Alluvium plot of epitopes grouped by Gene, HLA and TCR.