| Mutation type | Tumor type | No. of sample | No. of mutations | No. of neoantigens |
|---|---|---|---|---|
| SNV | Bladder | 408 | 74707 | 21070 |
| SNV | Brain | 151 | 16197 | 5227 |
| SNV | Breast | 982 | 62211 | 18238 |
| SNV | Cervix | 286 | 46607 | 11906 |
| SNV | Colorectal | 531 | 165293 | 39116 |
| SNV | Head and Neck | 495 | 55968 | 13728 |
| SNV | Kidney | 681 | 26170 | 8499 |
| SNV | Liver | 358 | 28024 | 5987 |
| SNV | Lung | 999 | 212861 | 52801 |
| SNV | Ovary | 305 | 28478 | 7631 |
| SNV | Pancreas | 166 | 17221 | 3985 |
| SNV | Prostate | 493 | 16424 | 5363 |
| SNV | Skin | 466 | 206907 | 43882 |
| SNV | Stomach | 411 | 103103 | 24497 |
| SNV | Thyroid | 488 | 4425 | 1218 |
| SNV | Uterus | 528 | 415499 | 109125 |
| INDEL | Bladder | 389 | 2890 | 3532 |
| INDEL | Brain | 130 | 366 | 375 |
| INDEL | Breast | 888 | 5207 | 6123 |
| INDEL | Cervix | 257 | 3095 | 4234 |
| INDEL | Colorectal | 520 | 21327 | 29876 |
| INDEL | Head and Neck | 478 | 3569 | 4913 |
| INDEL | Kidney | 648 | 5318 | 6395 |
| INDEL | Liver | 353 | 2120 | 2143 |
| INDEL | Lung | 983 | 10790 | 12407 |
| INDEL | Ovary | 296 | 4260 | 4441 |
| INDEL | Pancreas | 141 | 457 | 806 |
| INDEL | Prostate | 416 | 1448 | 2119 |
| INDEL | Skin | 430 | 1965 | 2557 |
| INDEL | Stomach | 393 | 19912 | 24838 |
| INDEL | Thyroid | 248 | 1746 | 1657 |
| INDEL | Uterus | 516 | 27934 | 30714 |
| Fusion | Bladder | 269 | 809 | 819 |
| Fusion | Brain | 92 | 244 | 245 |
| Fusion | Breast | 787 | 3390 | 3457 |
| Fusion | Cervix | 139 | 280 | 215 |
| Fusion | Colorectal | 167 | 328 | 231 |
| Fusion | Head and Neck | 285 | 532 | 530 |
| Fusion | Kidney | 171 | 318 | 420 |
| Fusion | Liver | 179 | 513 | 423 |
| Fusion | Lung | 716 | 1992 | 710 |
| Fusion | Ovary | 316 | 983 | 609 |
| Fusion | Pancreas | 72 | 130 | 161 |
| Fusion | Prostate | 381 | 1079 | 1120 |
| Fusion | Skin | 287 | 841 | 918 |
| Fusion | Stomach | 178 | 559 | 486 |
| Fusion | Thyroid | 110 | 140 | 250 |
| Fusion | Uterus | 85 | 501 | 499 |
About TSNAdb v2.0
TSNAdb v2.0 combines the predcited results of DeepHLApan, MHCflurry and NetMHCpan v4.0 for the identification of higher confidence neoantigens derived from SNV, INDEL and Fusion, respectively. Totally, 372,273 SNV-derived neoantigens, 137,130 INDEL-derived neoantigens and 11,093 Fusion-derived neoantigens are obtained. It also provides shared predicted neoantigens and 1,856 neoantigens collected from databases (dbPepNeo,NeoPeptide, NEPdb, CAPD) and literature .In these neoantigens, corresponding genes and mutations are linked to CandrisDB (cancer driver sites database) we created previously, providing more convincible information since neoantigen derived from driver genes or sites would be ideal tumor immunotherapy targets.
The previous version of TSNAdb is here.Contact
E-mail: zhanzhou@zju.edu.cn
Address: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.