Mutational Landscape
TCGA
ICGC
Q(z) Distribution of all mutated sites in a driver gene
Sites: the mutated amino acid site.
Q(z): the posterior probability of an amino acid site being a cancer-driving when the number (z) of somatic mutations is observed at this site.
Driver Gene
Methods
Evolutionary selective pressure(dN/dS) based: CNCS_calculator dNdScv CBaSEMutation frequency based: MuSiC MuSig2CV OncodriveCLUST
Feature(e.g. functional impact) based: 20/20+ CompositeDriver OncodriveFML
Structural(Domain) based: e-Driver ActiveDriver
Omic/Network or pathway based: DriverNet OncoIMPACT PNC
Machine learning based: DriverML
In pan-cancer level:
Across tumor types: