CanDriS – CandrisDB CanDriS Server

CanDriS Webserver Task

CanDriS is a software which uses an empirical Bayesian procedure to calculate the posterior probability of a site to be cancer-driving for all sites in a gene. To use it, please upload a mutation annotation format (maf) file that contains the somatic point mutations that are to be investigated. The file should contain the following four tab-delimited columns in the given order (including a header):

(1) Gene id
– corresponds to the official gene id as used in the Ensembl 75: Feb 2014(GRCh37.p13); for example, ENSG00000084734
(2) Transcript id
- the transcript which is most commonly used in TCGA, can be downloaded from this reference file; for example, ENST00000264717
(3) DNA mutation
– the allele change in the mutation site; for example, 1740C>A
(4) Protein mutation
– the amino acid change in the mutation site; for example, F580L
(5) Mutation count
– the mutation frequency in your own cohort
The example file:
gene_id trancript_id DNA_mutation protein_mutation mutation_count
ENSG00000084734 ENST00000264717 1740C>A F580L 1
ENSG00000120669 ENST00000379881 389G>A S130N 1
ENSG00000011258 ENST00000415868 547A>G T183A 1
ENSG00000160716 ENST00000368476 758T>C I253T 1
ENSG00000141867 ENST00000263377 3139C>T R1047W 1

By default, you can run CanDriS just based on your own data if you have a big enough cohort or a unique tumor type samples differ from TCGA. Alternatively, you can also choose to run CanDriS by merging your sample into TCGA MC3 PANCAN or a specific tumor type data.

In the web page, we only display the sites with a posterior posibility over 0.5 for convenient. The complete result can be downloaded from the "Download" button at the bottom of the page.

Runtime depends on server usage and the size of the data set. Enter your e-mail address to receive the results when they are ready. Alternatively, you can keep the browser window open and check back later. It won't take a long time.

Upload mutation data file:
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