#: Equal contributor; *: Corresponding author

  • Zhou Z#,*, Wu J#, Ren J, Chen W, Zhao W, Gu X, Chi Y, He Q, Yang B, Wu J*, Chen S*. TSNAD v2.0: A one-stop software solution for tumor-specific neoantigen detection, Comput Struct Biotechnol J, 2021, 19:4510-4516.   doi:10.1016/j.csbj.2021.08.016.
  • Zhao W#, Yang J#, Wu J, Cai G, Zhang Y, Haltom J, Su W, Dong M. Chen S, Wu J, Zhou Z*, Gu X*, CanDriS: posterior profiling of cancer-driving sites based on two-component evolutionary model, Brief Bioinform, 2021, In Press.   doi:10.1093/bib/bbab131
  • Wu S#, Haltom J#, Zhao W, Yang J, Zhou Z*, Gu X*. Evolution and functional divergence of the ERBB receptor family, Pharmacogenomics, 2021, 22(8): 473-484.   doi:10.2217/pgs-2020-0158
  • Gu J*, Zhou Z*, Wang Y*. Editorial: Evolutionary Mechanisms of Infectious Diseases, Front Microbiol, 2021, 12:667561.   doi:10.3389/fmicb.2021.667561
  • Wang H#, Ding Y#, Chen Y#, Jiang J, Chen Y, Lu J, Kong M, Mo F, Huang Y, Zhao W, Fang P, Chen X, Teng X, Xu N, Lu Y, Yu X, Li Z, Zhang J, Wang H, Bao X, Zhou D, Chi Y, Zhou T, Zhou Z*, Chen S*, Teng L*. A novel genomic classification system of gastric cancer via integrating multidimensional genomic characteristics, Gastric Cancer, 2021, In Press,   doi:10.1007/s10120-021-01201-9
  • Lu J#, Ding Y#, Chen Y#, Jiang J, Chen Y, Huang Y, Wu M, Li C, Kong M, Zhao W, Wang H, Zhang J, Li Z, Lu Y, Yu X, Jin K, Zhou D, Zhou T, Zhou Z*, Wang H*, Teng L*, Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma (AFPGC) reveals genomic profile and therapeutic targets, Nat Commun, 2021, 12:3946.   doi:10.1038/s41467-021-24170-0
  • Zhao WB, Shen Y, Liu WH, Li YM, Jin SJ, Xu YC, Pan LQ, Zhou Z*, Chen SQ*, Soluble Expression of Fc-Fused T Cell Receptors Allows Yielding Novel Bispecific T Cell Engagers, Biomedicines, 2021, 9(7):790.   doi:10.3390/biomedicines9070790
  • Wei R, Li P, He F, Wei G, Zhou Z, Su Z*, Ni T*, Comprehensive analysis reveals distinct mutational signature and its mechanistic insights of alcohol consumption in human cancers, Brief Bioinform, 2021, 22(3): bbaa066.   doi:10.1093/bib/bbaa066
  • Qi M#, Zhang B#, Jiang L, Xu S, Dong C, Du YL, Zhou Z, Huang L, Xu Z, Lian J*, PCR & Go: A Pre-installed Expression Chassis for Facile Integration of Multi-Gene Biosynthetic Pathways, Front Bioeng Biotechnol, 2021, 8:613771.   doi:10.3389/fbioe.2020.613771
  • Yang X#, Fan J#, Wu Y#, Ma Z, Huang J, Zhang Y, Zhou Z, Mo F, Liu X, Yuan H, Xu Y, Pan L*, Chen S*. Synthetic multiepitope neoantigen DNA vaccine for personalized cancer immunotherapy. Nanomedicine, 2021, 37:102443.   doi:10.1016/j.nano.2021.102443
  • Fan J, Zhuang X, Yang X, Xu Y, Zhou Z, Pan L*, Chen S*. A multivalent biparatopic EGFR-targeting nanobody drug conjugate displays potent anticancer activity in solid tumor models. Signal Transduct Target Ther, 2021, 6(1):320.   doi:10.1038/s41392-021-00666-5.
  • Bai X, Liu W, Jin S, Zhao W, Xu Y, Zhou Z, Chen S*, Pan L*. Facile Generation of Potent Bispecific Fab via Sortase A and Click Chemistry for Cancer Immunotherapy. Cancers, 2021, 13:4540.   doi:10.3390/cancers13184540.


  • Wu J, Chen W, Zhou J, Zhao W, Sun Y, Zhu H, Yao P, Chen S, Jiang J*, Zhou Z*, COVIEdb: A database for potential immune epitopes of coronaviruses, Front Pharmacol, 2020, 11:572249   doi:10.3389/fphar.2020.572249
  • Yang X, Ma Z, Zhang Y, Wu J, Huang J, Zhao W, Mo F, Lin Z, Xu Y, Zhou Z*, Chen S*. Anti-tumor immune response varies among individuals: A gene expression profiling of mouse melanoma. Int Immunopharmacol, 2020, 80:106211.   doi:10.1016/j.intimp.2020.106211
  • Zhao W, Wu J, Chen S, Zhou Z*, Shared neoantigens: ideal targets for off-the-shelf cancer immunotherapy. Pharmacogenomics, 2020, 21(9): 637-645.   doi:10.2217/pgs-2019-0184
  • Zhang Y, Wu S, Zhuang X, Weng G, Fan J, Yang X, Xu Y, Pan L, Hou T, Zhou Z*, Chen S*. Identification of an Activating Mutation in the Extracellular Domain of HER2 Conferring Resistance to Pertuzumab. Onco Targets Ther, 2019, 12:11597-11608.   doi:10.2147/OTT.S232912
  • Liu W#, Zhao W#, Bai X, Jin S, Li Y, Qiu C, Pan L, Ding D, Xu Y, Zhou Z*, Chen SQ*. High antitumor activity of Sortase A-generated anti-CD20 antibody fragment drug conjugates. Eur J Pharm Sci, 2019, 134:81-92.   doi:10.1016/j.ejps.2019.04.015
  • Wu J, Wang W, Zhang J, Zhou B, Zhao W, Su Z, Gu X, Wu J, Zhou Z*, Chen S*. DeepHLApan: A deep learning approach for neoantigen prediction considering both HLA-peptide binding and immunogenicity. Front Immunol, 2019, 10: 2559.   doi:10.3389/fimmu.2019.02559
  • Shen Y, Wei X, Jin S, Wu Y, Zhao W, Xu Y, Pan L, Zhou Z, Chen S*, TCR-Mimic Antibody-Drug Conjugates Targeting Intracellular Tumor-Specific Mutant Antigen KRAS G12V Mutation, Asian J Pharm Sci, 2020, 15(6): 777-785.   doi:10.1016/j.ajps.2020.01.002
  • Fang Y#, Mo F#, Shou J#, Wang H, Luo K, Zhang S, Han N, Li H, Ye S, Zhou Z, Chen R, Chen L, Liu L, Wang H, Pan H*, Chen S*, A pan-cancer clinical study of personalized neoantigen vaccine monotherapy in treating patients with various types of advanced solid tumors, Clin Cancer Res, 2020, 26(17):4511-4520.   doi:10.1158/1078-0432.CCR-19-2881
  • Qiu CX, Bai XF, Shen Y, Zhou Z, Pan LQ, Xu YC, Zhao WB*, Chen SQ*, Specific Inhibition of Tumor Growth by T Cell Receptor-Drug Conjugates Targeting Intracellular Cancer-Testis Antigen NY-ESO-1/LAGE-1, Bioconjug Chem, 2020, 31(12):2767-2778.   doi:10.1021/acs.bioconjchem.0c00548
  • He F, Wei R, Zhou Z, Huang L, Wang Y, Tang J, Zou Y, Shi L, Gu X, Davis MJ, Su Z*. Integrative Analysis of Somatic Mutations in Non-coding Regions Altering RNA Secondary Structures in Cancer Genomes. Sci Rep, 2019, 9:8205.   doi:10.1038/s41598-019-44489-5
  • Zhou J#, Zhao WY#, Wu JC, Lu J, Ding YF, Wu SS, Wang HY, Ding D, Mo F, Zhou Z, Teng LS*, Chen SQ*. Neoantigens Derived from Recurrently Mutated Genes as Potential Immunotherapy Targets for Gastric Cancer. Biomed Res Int, 2019, 2019: 8103142.   doi:10.1155/2019/8103142
  • Shen Y, Li YM, Zhou JJ, Zhou Z, Xu YC, Zhao WB*, Chen SQ*. The Antitumor Activity of TCR-Mimic Antibody-Drug Conjugates (TCRm-ADCs) Targeting the Intracellular Wilms Tumor 1 (WT1) Oncoprotein. Int J Mol Sci, 2019, 20(16): 3912.   doi:10.3390/ijms20163912
  • Sharma A, Merritt E, Hu X, Cruz A, Jiang C, Sarkodie H, Zhou Z, Malhotra J, Riedlinger GM, De S*. Non-Genetic Intra-Tumor Heterogeneity Is a Major Predictor of Phenotypic Heterogeneity and Ongoing Evolutionary Dynamics in Lung Tumors. Cell Rep, 2019, 29:2164-2174 e2165.   doi:10.1016/j.celrep.2019.10.045


  • Zhao WB#, Qiu CX#, Shen Y, Liu WH, Zhou J, Xu YC, Zhou Z*, Chen SQ*. In situ quantitative bioanalysis of monomethyl auristatin E-conjugated antibody-drug conjugates by flow cytometry. Eur J Pharm Sci, 2018, 120:89-95.   doi:10.1016/j.ejps.2018.04.046
  • Wu J, Zhao W, Zhou B, Su Z, Gu X, Zhou Z*, Chen SQ*. TSNAdb: a database for tumor-specific neoantigens from immunogenomics data analysis. Genomics Proteomics Bioinformatics. 2018, 16(4):276-282.   doi:10.1016/j.gpb.2018.06.003
  • Ahmed S, Zhou J, Zhou Z*, Chen SQ*. Genetic Polymorphisms and in silico Mutagenesis analyses of CYP2C9, CYP2D6 and CYPOR Genes in Pakistani Population. Genes. 2018, 9(10):514.   doi:10.3390/genes9100514
  • Zhou Z#, Lyu X#, Wu J, Yang X, Wu S, Zhou J, Gu X, Su Z*, Chen SQ*. TSNAD: an integrated software for cancer somatic mutation and tumour-specific neoantigen detection. R Soc Open Sci. 2017, 4: 170050.   doi:10.1098/rsos.170050
  • Zhou Z#, Wu S#, Lai J, Shi Y, Qiu C, Chen Z, Wang Y, Gu X, Zhou J*, Chen SQ*: Identification of trunk mutations in gastric carcinoma: a case study. BMC Med Genomics, 2017, 10(1):49.   doi:10.1186/s12920-017-0285-y
  • Zhou Z#, Zou Y#, Liu G, Zhou J, Wu J, Zhao S, Su Z*, Gu X*. Mutation-profile-based methods for understanding selection forces in cancer somatic mutations: a comparative analysis. Oncotarget, 2017, 8(35):58835-58846.   doi:10.18632/oncotarget.19371
  • Wu JC, Lv XZ, Lei YJ, Zhou J, Zhou Z*, Chen SQ*. Analysis of online Mendelian inheritance in man. Chinese Journal of Biochemical Pharmaceutics, 2017, 37(3):1-4.
  • Lai J, Wang Y, Wu SS, Ding D, Sun ZY, Zhang Y, Zhou J, Zhou Z, Xu YC, Pan LQ* and Chen SQ*. Elimination of melanoma by sortase A-generated TCR-like antibody-drug conjugates (TL-ADCs) targeting intracellular melanoma antigen MART-1. Biomaterials. 2018, 178:158-169.   doi:10.1016/j.biomaterials.2018.06.017
  • Zhang D, Zhou LF, Lei YJ, Zhou Z, Zhou J*, Chen SQ*. Investigation of diethylstilbestrol residue level in human urine samples by a specific monoclonal antibody. Environ Sci Pollut Res Int, 2017, 24(8):7042-7050.   doi:10.1007/s11356-017-8405-y
  • Lv LX#, Zhou ZX#, Zhou Z, Zhang LJ, Yan R, Zhao Z, Yang LY, Bian XY, Jiang HY, Li YD, Sun YS, Xu QQ, Hu GL, Guan WJ*, Li YQ*, Hispidin induces autophagic and necrotic death in SGC-7901 gastric cancer cells through lysosomal membrane permeabilization by inhibiting tubulin polymerization, Oncotarget, 2017, 8(16): 26992-27006.   doi:10.18632/oncotarget.15935




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