{"id":2,"date":"2017-12-29T14:37:23","date_gmt":"2017-12-29T14:37:23","guid":{"rendered":"https:\/\/pgx.zju.edu.cn\/wordpress\/?page_id=2"},"modified":"2022-03-16T12:05:06","modified_gmt":"2022-03-16T12:05:06","slug":"sample-page","status":"publish","type":"page","link":"https:\/\/pgx.zju.edu.cn\/tsnadb1\/","title":{"rendered":"Home"},"content":{"rendered":"
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Welcome to T<\/span>umor-S<\/span>pecific N<\/span>eoA<\/span>ntigen d<\/span>atab<\/span>ase (TSNAdb v1.0)!<\/strong><\/h1>\n

\u00a0 \u00a0 \u00a0 \u00a0 Tumor-specific neoantigens have attracted much attention since they can be used as biomarkers to predict therapeutic effects of immune checkpoint blockade therapy and potential targets for cancer immunotherapy.<\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0 TNSAdb v1.0<\/span><\/strong> is developed based on pan-cancer immunogenomic analyses of somatic mutation data and human leukocyte antigen (HLA) allele information for 16 tumor types with 7748 tumor samples from The Cancer Genome Atlas (TCGA<\/strong>) and The Cancer Immunome Atlas (TCIA<\/strong>).<\/span><\/span> We predicted binding affinities between mutant\/wild-type peptides and HLA class I molecules by <\/span>NetMHCpan 2.8 (4.0) <\/strong>and presented detailed information of 3,707,562<\/strong>\u00a0(1,298,601<\/strong>) potential neoantigens generated by somatic mutations of all tumor samples.<\/p>\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
Tissue<\/th>Project<\/th>No. of sample<\/th>No. of HLA alleles<\/th>No. of mutation<\/th>No. of neoantigen
\n predicted by NetMHCpan 2.8<\/th>		No. of neoantigen
\n predicted by NetMHCpan 4.0<\/th>\n<\/tr>\n<\/thead>\n
Bladder<\/a><\/td>BLCA<\/td>408<\/td>106<\/td>49537<\/td>182756<\/td>65186<\/td>\n<\/tr>\n
Brain<\/a><\/td>GBM<\/td>151<\/td>82<\/td>11737<\/td>47521<\/td>15117<\/td>\n<\/tr>\n
Breast<\/a><\/td>BRCA<\/td>982<\/td>124<\/td>41895<\/td>159059<\/td>56197<\/td>\n<\/tr>\n
Cervix<\/a><\/td>CESC<\/td>286<\/td>119<\/td>31558<\/td>111558<\/td>38787<\/td>\n<\/tr>\n
Colorectal<\/a><\/td>COAD READ<\/td>531<\/td>133<\/td>108520<\/td>401274<\/td>131513<\/td>\n<\/tr>\n
Head and Neck<\/a><\/td>HNSC<\/td>495<\/td>107<\/td>37114<\/td>135822<\/td>48526<\/td>\n<\/tr>\n
Kidney<\/a><\/td>KICH KIRC KIRP<\/td>681<\/td>124<\/td>17676<\/td>66492<\/td>23648<\/td>\n<\/tr>\n
Liver<\/a><\/td>LIHC<\/td>358<\/td>115<\/td>19073<\/td>75449<\/td>24392<\/td>\n<\/tr>\n
Lung<\/a><\/td>LUAD LUSC<\/td>999<\/td>120<\/td>143449<\/td>554133<\/td>194553<\/td>\n<\/tr>\n
Ovary<\/a><\/td>OV<\/td>305<\/td>98<\/td>18938<\/td>70955<\/td>25148<\/td>\n<\/tr>\n
Pancreas<\/a><\/td>PAAD<\/td>166<\/td>73<\/td>11214<\/td>36266<\/td>16092<\/td>\n<\/tr>\n
Prostate<\/a><\/td>PRAD<\/td>493<\/td>102<\/td>12262<\/td>49046<\/td>16380<\/td>\n<\/tr>\n
Skin<\/a><\/td>SKCM<\/td>466<\/td>103<\/td>129201<\/td>510319<\/td>190139<\/td>\n<\/tr>\n
Stomach<\/a><\/td>STAD<\/td>411<\/td>121<\/td>69172<\/td>262356<\/td>85283<\/td>\n<\/tr>\n
Thyroid<\/a><\/td>THCA<\/td>488<\/td>120<\/td>2779<\/td>10904<\/td>3721<\/td>\n<\/tr>\n
Uterus<\/a><\/td>UCEC<\/td>528<\/td>153<\/td>268062<\/td>1033652<\/td>363919<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Welcome to Tumor-Specific NeoAntigen database (TSNAdb v1.0)! \u00a0 \u00a0 \u00a0 \u00a0 Tumor-specific neoantigens have attracted much attention since they can be used as biomarkers to predict therapeutic effects of immune…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"main.php","meta":{"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry","entry","simple"],"_links":{"self":[{"href":"https:\/\/pgx.zju.edu.cn\/tsnadb1\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pgx.zju.edu.cn\/tsnadb1\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pgx.zju.edu.cn\/tsnadb1\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pgx.zju.edu.cn\/tsnadb1\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pgx.zju.edu.cn\/tsnadb1\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":124,"href":"https:\/\/pgx.zju.edu.cn\/tsnadb1\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":727,"href":"https:\/\/pgx.zju.edu.cn\/tsnadb1\/wp-json\/wp\/v2\/pages\/2\/revisions\/727"}],"wp:attachment":[{"href":"https:\/\/pgx.zju.edu.cn\/tsnadb1\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}