@import url('https://fonts.googleapis.com/css2?family=Open+Sans:wght@500&family=Poppins:wght@300&display=swap');

@media (min-width: 768px) {
	.news-input {
		width: 50%;
	}
}

html,
body {
	font-family: 'Open Sans', 'Helvetica Neue', 'Helvetica', 'Arial', 'sans-serif';
	/* background: url('../images/bg.jpg'); */
	height: 100%;
	margin: 0;
	padding: 0;
	/* text-align:center; */
}

h2,
h3 {
	font-family: Gotham Bold;
}

/* b, h3, h4, h5, h6 {
    font-family: 'Open Sans', "sans-serif";
} */

p {
	color: #283e5d;
	margin-bottom: 0.75rem;
	text-align: justify;
	/* text-align-last:justify; */
}

.aligned_text {
	font-size: 24px;
	text-align: center;
	color: #115481;
}

.home_a {
	border-radius: 0;
	display: block;
	background: #fff;
	text-decoration: none;
	width: auto;
	padding: 0.75rem 1rem;
}

select {
	border-color: #c2c2c2;
	margin-right: 1rem;
}

img {
	max-width: 100%;
	max-height: 100%;
}

ul {
	padding-left: 0.15rem;
}

.graph {
	width: 100%;
	padding-bottom: 20px;
}

a.oncotrimd_a {
	color: #166aa2;
}

label {
	display: inline-block;
	margin-bottom: 0.5rem;
	font-weight: bold;
}

.tooltip {
	position: absolute;
	z-index: 1030;
	display: block;
	visibility: visible;
	font-size: 0.75rem;
	line-height: 1.25rem;
	opacity: 0;
	filter: alpha(opacity=0);
}

.tooltip.in {
	opacity: 0.8;
	filter: alpha(opacity=80);
}

.tooltip.top {
	margin-top: -3px;
	padding: 5px 0;
}

.tooltip.right {
	margin-left: 3px;
	padding: 0 5px;
}

.tooltip.bottom {
	margin-top: 3px;
	padding: 5px 0;
}

.tooltip.left {
	margin-left: -3px;
	padding: 0 5px;
}

.tooltip-inner {
	padding: 3px 8px 2px;
	max-width: 800px;
	border-radius: 2px;
	background-color: #27937b;
	color: #fff;
	text-align: center;
	text-decoration: none;
	opacity: 0.9;
	filter: alpha(opacity=90);
}

.tooltip-arrow {
	position: absolute;
	width: 0;
	height: 0;
	border-color: transparent;
	border-style: solid;
}

.tooltip.top .tooltip-arrow {
	bottom: 0;
	left: 50%;
	margin-left: -5px;
	border-width: 5px 5px 0;
	opacity: 0.9;
	border-top-color: #27937b;
	filter: alpha(opacity=90);
}

.tooltip.right .tooltip-arrow {
	top: 50%;
	left: 0;
	margin-top: -5px;
	border-width: 5px 5px 5px 0;
	opacity: 0.9;
	border-right-color: #27937b;
	filter: alpha(opacity=90);
}

.tooltip.left .tooltip-arrow {
	top: 50%;
	right: 0;
	margin-top: -5px;
	border-width: 5px 0 5px 5px;
	opacity: 0.9;
	border-left-color: #27937b;
	filter: alpha(opacity=90);
}

.tooltip.bottom .tooltip-arrow {
	top: 0;
	left: 50%;
	margin-left: -5px;
	border-width: 0 5px 5px;
	opacity: 0.9;
	border-bottom-color: #27937b;
	filter: alpha(opacity=90);
}

/* ****************************************** Block ****************************************** */
.candris-header-main {
	background-color: #fafafa;
	margin-bottom: 0.1rem;
}

.candris-footer-main {
	background-color: #2671a3;
	padding-bottom: 0.1rem;
}

/* .candris-footer2-main {
	background-color: #2671a3;
	padding: 1rem 4rem;
} */

.container {
	padding: 0%;
	/* width: 50rem;
	box-shadow:1px 1px 0px #fff;
	box-shadow: 0 .5rem 1rem rgba(0, 0, 0, .15);
    border:1px solid #cccfcf;
    border-radius: .25rem;
	border-bottom-right-radius: 10px;
    border-bottom-left-radius: 10px; */
}

.container.body-main {
	margin-top: 2rem;
	margin-bottom: 0.25rem;
	color: #283e5d;
}

.container.body-main-frame {
	margin-top: 2rem;
	background-color: #fff;
	box-shadow: 0 0.5rem 1rem rgba(0, 0, 0, 0.1);
	margin-bottom: 2rem;
}

.container.body-main-frameheader {
	background-color: #ecf9fe;
	/* margin-top: 2rem; */
	padding: 15px 20px 10px;
	color: #283e5d;
}
.container.body-main-framebody {
	padding: 15px 30px;
	color: #283e5d;
}

.small-block {
	padding: 15px 20px;
	color: #283e5d;
	background-color: #fafafa;
}

.tab-container {
	background-color: #fff;
	padding: 5px 20px;
}

.tab-panel {
	margin: 10px 0;
}

.tab-content {
	height: auto;
	margin: 5px 10px;
	padding: 0 10px;
	border-left: 2px solid #f2f2f2;
	border-right: 2px solid #f2f2f2;
	border-bottom: 2px solid #f2f2f2;
}

/* **********************************************Header********************************************** */
.container.header-main {
	font-weight: 200;
	background-color: #fafafa;
	/* box-shadow: 0 0 10px 0 rgb(0 0 0 / 10%);
	color: #fff;
	padding: 30px 30px 15px; */
	padding-top: 20px;
	padding-bottom: 0px;
}

.container.header-main2 {
	display: table;
	width: 100%;
	background-color: #fafafa;
	padding-top: 5px;
	padding-bottom: 10px;
}

.container.header-main2 #nav__logo {
	width: 30%;
	white-space: nowrap;
	display: table-cell;
	vertical-align: middle;
}

.nav {
	font-size: 1.5rem;
}

.nav__pages {
	/* margin: .5rem 0; */
	display: table-cell;
	vertical-align: middle;
	text-align: center;
	width: 38%;
}

.nav__actions {
	display: table-cell;
	text-align: right;
	margin-right: 0;
	width: 27%;
}

.nav__items {
	position: relative;
}

.nav__items__item {
	background-color: transparent;
	display: inline;
	text-align: left;
	margin: 1rem 0.5rem 2rem 0.5rem;
}

.nav__items__item a,
.nav__items__item a:active,
.nav__items__item a:visited {
	border-radius: 0;
	display: block;
	background: #fff;
	text-decoration: none;
	width: auto;
	padding-right: 1.5rem;
}

@media (min-width: 721px) {
	.nav__items__item a,
	.nav__items__item a:active,
	.nav__items__item a:visited {
		border-radius: 3rem;
	}
	.nav__items__item{
		display: inline-block;
	}
}

.nav__items__item a:hover {
	text-decoration: none;
}

.nav__items__item.nav__home a {
	color: #fff;
	border: 0.25rem solid #76a1bd;
	background: #76a1bd;
}


.nav__items__item.nav__cancer a {
	color: #fff;
	border: 0.25rem solid #e9931c;
	background: #e9931c;
}

.nav__items__item.nav__cancer a:hover {
	color: #e9931c;
	background: #fff;
}

.nav__items__item.nav__mutation a:hover {
	color: #76a1bd;
	background: #fff;
}

.nav__items__item.nav__mutation a {
	color: #fff;
	border: 0.25rem solid #1693c0;
	background: #1693c0;
}

.nav__items__item.nav__mutation a:hover {
	color: #1693c0;
	background: #fff;
}

.nav__items__item.nav__gene a {
	color: #fff;
	border: 0.25rem solid #9b315b;
	background: #9b315b;
}

.nav__items__item.nav__gene a:hover {
	color: #9b315b;
	background: #fff;
}

.nav__items__item.nav__network a {
	color: #fff;
	border: 0.25rem solid #6a9c5b;
	background: #6a9c5b;
}

.nav__items__item.nav__network a:hover {
	color: #6a9c5b;
	background: #fff;
}

.nav__items__item.nav__noncoding a {
	color: #fff;
	border: 0.25rem solid #166aa2;
	background: #166aa2;
}

.nav__items__item.nav__noncoding a:hover {
	color: #166aa2;
	background: #fff;
}

.nav__items__item.nav__tool a {
	color: #fff;
	border: 0.25rem solid #ed8829;
	background: #ed8829;
}

.nav__items__item.nav__tool a:hover {
	color: #ed8829;
	background: #fff;
}

.nav__items__item.nav__tool .submenu {
	position: absolute;
	/* border: .1rem solid #ed8829; */
	min-width: 60px;
	background-color: #fafafa;
	overflow: hidden;
	opacity: 0;
	visibility: hidden;
}

.nav__items__item.nav__tool:hover .submenu {
	position: absolute;
	z-index: 2;
	opacity: 1;
	visibility: visible;
}

.nav__items__item.nav__tool ul {
	color: #ed8829;
}

.nav__items__item.nav__tool .submenu li a {
	color: #ed8829;
	background-color: #fafafa;
	font-weight: 200;
	font-size: 18px;
	/* line-height: 23px;
    text-transform: uppercase;
     */
	display: block;
	text-decoration: none !important;
	border-radius: 0;
	border-style: none;
	opacity: 0;
	visibility: hidden;
}

.nav__items__item.nav__tool .submenu li a:hover {
	color: #a4570e;
}

.nav__items__item.nav__tool:hover .submenu li a {
	opacity: 1;
	visibility: visible;
}

.nav__items__item__icon i {
	position: relative;
	display: inline-block;
	margin: 0 auto;
	padding: 0.8rem 1rem 0.8rem 1.1rem;
	border-radius: 50%;
	background: hsla(0, 0%, 100%, 0.1);
}

@media (min-width: 1025px) {
	.nav__items__item__icon i {
		padding: 0.8rem 1rem 0.9rem;
	}
}

@media (min-width: 1535px) {
	.nav__items__item__icon i {
		padding: 0.9rem;
	}
}

.nav__items__item__title {
	font-weight: 500;
	display: inline-block;
	padding-left: 0.5rem;
}



/********** Search page header *********/
.nav_home {
	font-size: 20px;
	color: #fff;
    border: 0.25rem solid #76a1bd;
    background: #76a1bd;
    border-radius: 3rem;
	text-decoration: none;
	margin-right: 0.5rem;
	margin-bottom: 1rem;
	text-align: left;
}
.nav_home:hover,
.nav_home.active {
	color: #76a1bd;
	background: #fff;
}

/* .nav__items__item__icon_home i {
	position: relative;
	display: inline-block;
	margin: 0 auto;
	padding: 0.8rem 0rem 0.8rem 0rem;
	border-radius: 50%;
	background: hsla(0, 0%, 100%, 0.1);
}

@media (min-width: 1025px) {
	.nav__items__item__icon_home i {
		padding: 0.8rem 0rem 0.9rem;
	}
}

@media (min-width: 1535px) {
	.nav__items__item__icon_home i {
		padding: 0.9rem;
	}
} */


.nav_cancer {
	font-size: 20px;
	color: #fff;
    border: 0.25rem solid #e9931c;
    background: #e9931c;
    border-radius: 3rem;
	text-decoration: none;
	margin-right: 0.5rem;
	margin-bottom: 1rem;
}
.nav_cancer:hover,
.nav_cancer.active {
	color: #e9931c;
	background: #fff;
}


.nav_mutation {
	font-size: 20px;
	color: #fff;
	border: 0.25rem solid #1693c0;
	background: #1693c0;
    border-radius: 3rem;
	text-decoration: none;
	margin-right: 0.5rem;
	margin-bottom: 1rem;
}
.nav_mutation:hover,
.nav_mutation.active {
	color: #1693c0;
	background: #fff;
}

.nav_gene {
	font-size: 20px;
	color: #fff;
    border: 0.25rem solid #9b315b;
    background: #9b315b;
    border-radius: 3rem;
	text-decoration: none;
	margin-right: 0.5rem;
	margin-bottom: 1rem;
}

.nav_gene:hover,
.nav_gene.active {
	color: #9b315b;
	background: #fff;
}

.nav_network {
	font-size: 20px;
	color: #fff;
    border: 0.25rem solid #6a9c5b;
    background: #6a9c5b;
    border-radius: 3rem;
	text-decoration: none;
	margin-right: 0.5rem;
	margin-bottom: 1rem;
}
.nav_network:hover,
.nav_network.active {
	color: #6a9c5b;
	background: #fff;
}

.nav_noncoding {
	font-size: 20px;
	color: #fff;
    border: 0.25rem solid #166aa2;
    background: #166aa2;
    border-radius: 3rem;
	text-decoration: none;
	margin-right: 0.5rem;
	margin-bottom: 1rem;
}
.nav_noncoding:hover,
.nav_noncoding.active {
	color: #166aa2;
	background: #fff;
}

.nav_tool {
	font-size: 20px;
	color: #fff;
    border: 0.25rem solid #ed8829;
    background: #ed8829;
    border-radius: 3rem;
	text-decoration: none;
	margin-right: 0.5rem;
	margin-bottom: 1rem;
}
.nav_tool:hover,
.nav_tool.active {
	color: #ed8829;
	background: #fff;
}

.nav_items_title {
	font-weight: 500;
    display: inline-block;
    /* padding-left: 0.5rem; */
}



/* ****************************************** search-navbar ****************************************** */
.nav-search {
	margin: 0 auto;
	position: relative;
	display: flex;
	padding: 0 10px;
	font-weight: 600;
	font-size: 1.2rem;
}

.nav-search.navbar-mutation li,
.nav-search.navbar-gene li,
.nav-search.navbar-cancer li {
	list-style-type: none;
	list-style: none;
	width: 25%;
	border-bottom: 2px solid #ddd;
	text-align: center;
	padding: 10px 5px;
}

.nav-search.navbar-mutation li a,
.nav-search.navbar-gene li a,
.nav-search.navbar-cancer li a {
	color: #166aa2;
	text-decoration: none !important;
}

.nav-search.navbar-mutation li a:hover,
.nav-search.navbar-gene li a:hover,
.nav-search.navbar-cancer li a:hover {
	color: #283e5d;
}

.nav-search.navbar-mutation .active,
.nav-search.navbar-gene .active,
.nav-search.navbar-cancer .active {
	border-top: 3px solid #3786c2 !important;
	text-decoration: none !important;
	border-bottom: 3px solid #fff !important;
	border-left: 2px solid #ddd !important;
	border-right: 2px solid #ddd !important;
}

.nav-search.navbar-network li {
	list-style-type: none;
	list-style: none;
	width: 50%;
	border-bottom: 2px solid #ddd;
	text-align: center;
	padding: 10px 5px;
}

.nav-search.navbar-network li a {
	color: #166aa2;
	text-decoration: none !important;
}

.nav-search.navbar-network li a:hover {
	color: #283e5d;
}

.nav-search.navbar-network .active {
	border-top: 3px solid #3786c2 !important;
	text-decoration: none !important;
	border-bottom: 3px solid #fff !important;
	border-left: 2px solid #ddd !important;
	border-right: 2px solid #ddd !important;
}

/* ****************************************** footer ****************************************** */
.container.footer-main {
	background-color: #2671a3;
	/* box-shadow: 10px 10px 10px 0 rgb(0 0 0 / 10%); */
	color: #fff;
	margin-top: 10px;
	padding: 15px 15px 5px 15px;
}

.container.footer-main a {
	color: #fff;
	text-decoration: underline;
}

.container.footer-main a:hover {
	color: #0e5686;
}

.footer__icon i {
	position: relative;
	display: inline-block;
	margin: 0 auto;
	/* padding: .8rem 1rem .8rem 1.1rem; */
	border-radius: 50%;
	background: hsla(0, 0%, 100%, 0.1);
}

@media (min-width: 1025px) {
	.footer__icon i {
		padding: 0.1rem 0.1rem 0.1rem;
	}
}

@media (min-width: 1535px) {
	.footer__icon i {
		padding: 0.1rem;
	}
}

/* ****************************************** Buttons ****************************************** */
button {
	background: #76b3fa;
	border-radius: 20px;
	padding: 5px 10px;
	color: #fff;
	text-decoration: none;
	font-size: 0.8em;
	margin: 5px 5px;
}

button:hover {
	-webkit-animation: hover 1200ms linear 2 alternate;
	animation: hover 1200ms linear 2 alternate;
	background-color: #fff;
	color: #76b3fa;
}

button:active {
	-webkit-animation: active 1200ms ease 1 alternate;
	animation: active 1200ms ease 1 alternate;
	background: #5f9be0;
}

button:disabled {
	background: #6d6d6d;
	-webkit-animation: none;
	animation: none;
}


.btn.launch {
	border-radius: 5px;
	color: #fff;
	background-color: #237ebb;
	line-height: 40px;
	font-size: 1.15rem;
	padding: 0 20px;
}

.btn.launch:hover {
	color: #fff;
	/* font-weight: bold; */
	background-color: #135b8b;
}

.btn.search {
	border: 0.15rem solid;
	border-color: #e9931c;
	border-radius: 0;
	text-align: center;
	background: #e9931c;
	color: #fff;
	padding: 0 10px 0 10px;
	font-size: 1.2em;
	/* line-height: 45px; */
	/* width: 100px; */
}

.btn.search:hover {
	background: #d58515;
	border: 0.15rem solid;
	border-color: #d58515;
}

.btn.example {
	border: 0.15rem solid;
	border-radius: 0;
	text-align: center;
	background: #fff;
	border-color: #0d6efd;
	color: #0d6efd;
	/* padding: 0 10px 0 10px; */
	font-size: 1.2em;
	/* line-height: 45px; */
	/* width: 100px; */
}

.btn.example:hover {
	background: #0d6efd;
	color: #fff;
	border: 0.15rem solid;
	border-color: #0d6efd;
}

.btn.btn-own {
	--bs-btn-color: #fff;
	--bs-btn-bg: #1a7cbd;
	--bs-btn-border-color: #1a7cbd;
	--bs-btn-hover-color: #1a7cbd;
	--bs-btn-hover-bg: #fff;
	--bs-btn-hover-border-color: #1a7cbd;
	--bs-btn-focus-shadow-rgb: 49, 132, 253;
	--bs-btn-active-color: #fff;
	--bs-btn-active-bg: #1a7cbd;
	--bs-btn-active-border-color: #1a7cbd;
	--bs-btn-active-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
	--bs-btn-disabled-color: #fff;
	--bs-btn-disabled-bg: #1a7cbd;
	--bs-btn-disabled-border-color: #1a7cbd;
}

/* 自定义button */
b.btn-query {
	color: #6c757d;
	font-size: 0.9rem;
    border-color: #6c757d;
}

.btn.btn-warning-own {
    --bs-btn-color: #000;
    --bs-btn-bg: #ffc107;
    --bs-btn-border-color: #ffc107;
    --bs-btn-hover-color: #000;
    --bs-btn-hover-bg: #ffca2c;
    --bs-btn-hover-border-color: #ffc720;
    --bs-btn-focus-shadow-rgb: 217, 164, 6;
    --bs-btn-active-color: #000;
    --bs-btn-active-bg: #ffcd39;
    --bs-btn-active-border-color: #ffc720;
    --bs-btn-active-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
    --bs-btn-disabled-color: #000;
    --bs-btn-disabled-bg: #ffc107;
    --bs-btn-disabled-border-color: #ffc107;
}


.search-box {
	background-color: #fff;
	border-radius: 0.3rem;
	padding: 10px;
	box-shadow: 0 10px 12px rgba(77, 60, 160, 0.1);
	margin-top: 0.5rem;
	margin-bottom: 1rem;
	display: flex;
	width: 100%;
}

.search-box .form-select {
	font-size: 1.25em;
	border-radius: 0rem;
	width: 25%;
	padding: 12px 15px;
	line-height: 29px;
	/* border-color: transparent; */
	transition: all 0.3s;
	margin-right: 0.5rem;
}


.search-box .home-search {
	font-size: 1.25em;
	width: 145px;
	background-color: #166aa2;
	border: 0.1rem solid;
	color: var(--bs-light);
	margin: 0 0;
}

.search-box .home-search:hover {
	background: #135b8b;
	border-color: #135b8b;
}


.switchbutton {
	border: 0.15rem solid;
	border-radius: 0;
	text-align: center;
	background: #1a7cbd;
	border-color: #1a7cbd;
	color: #fff;
	/* padding: 0 10px 0 10px; */
	font-size: 1.2em;
	/* line-height: 45px; */
	/* width: 100px; */
}

.switchbutton.active {
	background: #fff;
	color: #1a7cbd;
	border: 0.15rem solid;
	border-color: #1a7cbd;
}

.switchbutton2 {
	border: 0.15rem solid;
	border-radius: 0;
	text-align: center;
	background: #1a7cbd;
	border-color: #1a7cbd;
	color: #fff;
	/* padding: 0 10px 0 10px; */
	font-size: 1.2em;
	/* line-height: 45px; */
	/* width: 100px; */
}

.switchbutton2.active {
	background: #fff;
	color: #1a7cbd;
	border: 0.15rem solid;
	border-color: #1a7cbd;
}

/* ****************************************** Info ****************************************** */
.info-list {
	margin: 0.25rem 0 1rem 0;
	list-style: none;
}

.info-list--columns {
	column-count: 2;
	column-width: 50%;
}

.list-item {
	display: flex;
	align-items: baseline;
	padding: 0.25rem 0;
	align-items: stretch;
}

.list-item__title {
	flex-basis: 10vw;
	flex-shrink: 0;
	text-align: right;
	padding-right: 0.7rem;
}

.tiny {
	font-size: 1rem;
	font-weight: 600;
}

.list-item__content {
	flex-grow: 1;
	padding-left: 0.7rem;
	padding-top: 0.1rem;
	padding-bottom: 0.1rem;
	border-left: 0.125rem solid #00a6d5;
}

/* ****************************************** Help ****************************************** */
.card {
	border: 0;
	box-shadow: 0 10px 12px rgba(77, 60, 160, 0.1);
}

.sidebar {
	border-radius: 0.4rem;
	border: 1px solid #e6f0f7d6;
	margin-bottom: 30px;
	position: sticky;
	top: 20px;
	padding-bottom: 0.5rem;
	background-color:#e6f0f7d6;
}

.sidebar h5 {
	padding: 0.875rem 1rem;
	margin-bottom: 0;
	/* background-color: var(--bs-light); */
	border-radius: 0.4rem 0.4rem 0 0;
}

.sidebar .nav {
	display: block;
}

.sidebar .nav-pills .nav-item {
	font-size: 14px;
}

.sidebar .nav-link {
	position: relative;
	border-radius: 0;
	color: var(--bs-gray);
	transition: all 0.2s;
}

.sidebar .nav-link:hover {
	color: var(--bs-primary);
}

.sidebar .nav-link.active {
	color: #fff;
}

.nav-pills .nav-link {
	position: relative;
	padding: 0.15rem 0 0 1rem;
	/* background-color: var(--bs-light); */
	color: var(--bs-gray);
	transition: all 0.3s;
	border-radius: 0;
	--bs-nav-pills-link-active-bg: #166aa2;
}

.card-line {
	display: block;
	position: relative;
	width: 100%;
	height: 1px;
	background-color: #b2bacc;
	margin: 0px 0 20px 0;
}

.citation-item {
	display: block;
	position: relative;
	padding-left: 5px;
	padding-bottom: 5px;
	color: var(--bs-dark);
	text-decoration: none;
	text-align: justify;
}

.citation-item span {
	position: absolute;
	left: 0;
}

ul.detail{
	display: block;
	/* font-size: 4px; */
	list-style-type: none;
	padding-left: 1rem;
}

.article-title {
	/* font-size: 24px; */
	font-weight: 800;
	position: relative;
	padding-bottom: 1rem;
	margin-bottom: 1rem;
	margin-top: 0;
}

.sub-article-title {
    font-size: 24px;
    font-weight: 600;
    position: relative;
    padding-bottom: 1rem;
    /* margin-bottom: 1rem; */
    margin-top: 0;
    background-color: #e6f0f7;
    /* text-align: center; */
    width: 270px;
    padding: 8px 0px 8px 8px;
}

/* ****************************************** Mutation ****************************************** */
.info-card {
	display: block;
	text-align: left;
	overflow: hidden;
	white-space: nowrap;
	/* margin: 10px 5px 10px 5px; */
	/* margin-bottom: 15px; */
	/* color: #575757; */
	font-weight: 700;
	font-size: 16px;
}
.info-card > ul {
	border-left: 1px solid #e6e6e6;
	border-right: 1px solid #e6e6e6;
	border-bottom: 1px solid #e6e6e6;
	padding: 10px 0px 10px 0px;
	overflow: auto;
}

.info-card > ul li {
	padding: 4px;
}

.info-card > span {
	position: relative;
	display: inline-block;
	/* text-align: center; */
}

.info-card > span:after,
.info-card > span:before {
	content: '';
	position: absolute;
	top: 50%;
	width: 9999px;
	border-top: 1px solid #e6e6e6;
}
.info-card > span:before {
	right: 100%;
	margin-right: 15px;
}
.info-card > span:after {
	left: 100%;
	margin-left: 15px;
}
.hidden {
	display: none !important;
}

/* .badge-mapping {
	cursor: pointer;
} */
/* .badge-mapping:hover {
	opacity: 0.8;
} */

.badge {
	border-radius: 25px;
	margin-left: auto;
	line-height: 1;
	padding: 6px 10px;
	vertical-align: middle;
	font-weight: 400;
	font-size: 11px;
	border: 1px solid #fafafa;
}
.badge.bg-own {
	color: #077bb1;
	background-color: #fff;
	border-radius: 5px;
	border: 1px solid #a5a5a5;
}

@media (min-width: 768px) {
	.mapping-label {
		width: 22rem;
		border-right: 1px solid #f2f2f2;
	}
}
.mapping-label {
	display: inline-block;
	font-style: normal;
	font-weight: 700;
	padding-right: 0.5rem;
	margin-right: 0.5rem;
	font-size: 20px;
}
.mapping-detail {
	display: inline-block;
	font-style: normal;
	padding-right: 0.5rem;
	margin-right: 0.5rem;
	font-size: 18px;
}


@media (min-width: 768px) {
	.gene-mapping-label {
		text-align: right;
		width: 10rem;
		border-right: 3px solid #428bca;
	}
}
.gene-mapping-label {
	display: inline-block;
	font-style: normal;
	font-weight: 700;
	padding-right: 0.5rem;
	margin-right: 0.5rem;
	font-size: 18px;
	width: 15rem;
}
.gene-mapping-detail {
	display: inline-block;
	font-style: normal;
	padding-right: 0.5rem;
	margin-right: 0.5rem;
	font-size: 16px;
}

.gene-mapping-result-container {
	margin-top: 1rem;
	padding-top: 1rem;
	padding-left: 1rem;
	background-color: #fafafa;
	cursor: pointer;
	/* border: 1px solid #ddd; */
	/* border-radius: 10px; */
}
.gene-mapping-area.string .gene-mapping-result-container:hover {
	background-color: #369cef;
	color: white;
}
.gene-mapping-area.modig .gene-mapping-result-container:hover {
	background-color: #ee8ebc;
	color: white;
}

.info-card td {
	border-color: #f0f0f0;
	border-width: 1px;
	padding: 8px 10px;
	text-align: center;
}

.info-card .table-header {
	background-color: #fafafa;
	padding: 13px 8px;
	text-align: center;
	font-size: 18px;
}

.select-row {
	display: flex;
	flex-wrap: wrap;
	/* margin-right: 10px; */
	/* margin-left: 10px; */
}

.select-box {
	padding-right: 10px;
	padding-left: 0px;
	padding-bottom: 10px;
}

/* ****************************************** Noncoding ****************************************** */
.info-label {
	display: block;
	text-align: center;
	overflow: hidden;
	white-space: nowrap;
	margin-top: 5px;
	margin-bottom: 5px;
	color: #283e5d;
	font-weight: 700;
	font-size: 20px;
}

.info-label > span {
	position: relative;
	display: inline-block;
}

.info-label > span:after,
.info-label > span:before {
	content: '';
	position: absolute;
	top: 50%;
	width: 9999px;
	border-top: 1px solid #e6e6e6;
}

.info-label > span:before {
	right: 100%;
	margin-right: 15px;
}

.info-label > span:after {
	left: 100%;
	margin-left: 15px;
}

.info-callout-header {
	/* color: #428bca; */
	/* font-weight: bold; */
	font-size: 18px;
}

.bs-callout {
	padding: 40px;
	border: 1px solid #eee;
	border-left-width: 4px;
	border-radius: 4px;
}

.bs-callout-sm {
	border: 1px solid #eee;
	border-left-width: 4px;
	border-radius: 4px;
	margin-right: 5px;
	margin-left: 5px;
	margin-bottom: 4px;
	padding: 7px 15px;
}

.bs-callout-md,
.bs-callout-outline-md {
	margin-right: 5px;
	margin-left: 5px;
	margin-bottom: 4px;
	padding: 14px 14px 14px 20px;
}

.bs-callout-md {
	border: 1px solid #eee;
	border-left-width: 4px;
	border-radius: 4px;
}

.bs-callout-outline-md {
	border: 1px solid #eee;
	border-left-width: 1px;
	border-radius: 4px;
}

.bs-callout:empty {
	padding: 20px;
	margin: 0;
	border: none;
}

.bs-callout h4 {
	margin-top: 0;
	margin-bottom: 5px;
}

.bs-callout p:last-child {
	margin-bottom: 0;
}

.bs-callout code {
	border-radius: 3px;
}

.bs-callout + .bs-callout {
	margin-top: -5px;
}

.bs-callout-primary {
	border-left-color: #428bca;
}

.bs-callout-primary h4 {
	color: #428bca;
}

.bs-callout-success {
	border-left-color: #5cb85c;
}

.bs-callout-success h4 {
	color: #5cb85c;
}

.bs-callout-danger {
	border-left-color: #d9534f;
}

.bs-callout-danger h4 {
	color: #d9534f;
}

.bs-callout-warning {
	border-left-color: #f0ad4e;
}

.bs-callout-warning h4 {
	color: #f0ad4e;
}

.bs-callout-info {
	border-left-color: #5bc0de;
}

.bs-callout-info h4 {
	color: #5bc0de;
}

.bs-callout-default {
	border-left-color: #ed7520;
}

.bs-callout-default h4 {
	color: #ed7520;
}


/*fancy button*/
/* https://uiverse.io/all */
.button.fancy {
	--color: #166aa2;
	margin: 0 0;
	width: 145px;
	background-color: transparent;
	border-radius: .3em;
	position: relative;
	overflow: hidden;
	cursor: pointer;
	transition: .5s;
	/* font-weight: 400; */
	font-size: 1.25em;
	border: 0.1rem solid;
	font-family: inherit;
	text-transform: uppercase;
	color: var(--color);
	z-index: 1;
}

.button.fancy::before, .button.fancy::after {
	content: '';
	display: block;
	width: 50px;
	height: 50px;
	transform: translate(-50%, -50%);
	position: absolute;
	border-radius: 50%;
	z-index: -1;
	background-color: var(--color);
	transition: 1s ease;
}

.button.fancy::before {
	top: -1em;
	left: -1em;
}

.button.fancy::after {
	left: calc(100% + 1em);
	top: calc(100% + 1em);
}

.button.fancy:hover::before, .button.fancy:hover::after {
	height: 410px;
	width: 410px;
}

.button.fancy:hover {
	color: #fff;
}

.button.fancy:active {
	filter: brightness(.8);
}

   
.button.learn-more {
	position: relative;
	display: inline-block;
	cursor: pointer;
	outline: none;
	border: 0;
	vertical-align: middle;
	text-decoration: none;
	background: transparent;
	padding: 0;
	font-size: inherit;
	font-family: inherit;
	width: 12rem;
	height: auto;
}

.button.learn-more .circle {
	transition: all 0.45s cubic-bezier(0.65, 0, 0.076, 1);
	position: relative;
	display: block;
	margin: 0;
	width: 3rem;
	height: 3rem;
	background: #166aa2;
	border-radius: 1.625rem;
}

.button.learn-more .circle .icon {
	transition: all 0.45s cubic-bezier(0.65, 0, 0.076, 1);
	position: absolute;
	top: 0;
	bottom: 0;
	margin: auto;
	background: #fff;
}

.button.learn-more .circle .icon.arrow {
	transition: all 0.45s cubic-bezier(0.65, 0, 0.076, 1);
	left: 0.625rem;
	width: 1.125rem;
	height: 0.125rem;
	background: none;
}

.button.learn-more .circle .icon.arrow::before {
	position: absolute;
	content: "";
	top: -0.29rem;
	right: 0.0625rem;
	width: 0.625rem;
	height: 0.625rem;
	border-top: 0.125rem solid #fff;
	border-right: 0.125rem solid #fff;
	transform: rotate(45deg);
}

.button.learn-more .button-text {
	transition: all 0.45s cubic-bezier(0.65, 0, 0.076, 1);
	position: absolute;
	top: 0;
	left: 0;
	right: 0;
	bottom: 0;
	padding: 0.75rem 0;
	margin: 0 0 0 1.85rem;
	color: #166aa2;
	font-weight: 700;
	line-height: 1.6;
	text-align: center;
	text-transform: uppercase;
}

.button:hover .circle {
	width: 100%;
}

.button:hover .circle .icon.arrow {
	background: #fff;
	transform: translate(1rem, 0);
}
   
.button:hover .button-text {
	color: #fff;
}



/*animated action*/
.bell {
	width: 13px;
}

.bell path {
	fill: #166aa2;
}
  
.bell:hover {
	animation: bellRing 0.9s both;
}
/* bell ringing animation keyframes*/
@keyframes bellRing {
	0%,
	100% {
		transform-origin: top;
	}

	15% {
		transform: rotateZ(10deg);
	}

	30% {
		transform: rotateZ(-10deg);
	}

	45% {
		transform: rotateZ(5deg);
	}

	60% {
		transform: rotateZ(-5deg);
	}

	75% {
		transform: rotateZ(2deg);
	}
}


/* cancer page: card */
.cancer-card {
	padding: 1rem;
	background-color: #fff;
	box-shadow: 0 10px 15px -3px rgba(0, 0, 0, 0.1), 0 4px 6px -2px rgba(0, 0, 0, 0.05);
	max-height: 260px;
	border-radius: 20px;
	overflow-y:auto;
}
  
.title {
	display: flex;
	align-items: center;
}
  
.title span {
	position: relative;
	padding: 0.5rem;
	background-color: #166aa2;
	width: 1.5rem;
	height: 1.5rem;
	border-radius: 9999px;
}
  
.title span svg {
	position: absolute;
	top: 50%;
	left: 50%;
	transform: translate(-50%, -50%);
	color: #fff;
	height: 1rem;
}
  
.title-text {
	margin-left: 0.5rem;
	color: #374151;
	font-size: 24px;
}
  
.percent {
	margin-left: 0.5rem;
	color: #166aa2;
	font-weight: 600;
	display: flex;
}
  
.data {
	display: flex;
	flex-direction: column;
	justify-content: flex-start;
}
  
.data p {
	margin-top: 1rem;
	margin-bottom: 1rem;
	color: #1F2937;
	font-size: 2.25rem;
	line-height: 2.5rem;
	font-weight: 700;
	text-align: left;
}
  
.data .range {
	position: relative;
	background-color: #E5E7EB;
	width: 100%;
	height: 0.5rem;
	border-radius: 0.25rem;
}
  
.data .range .fill {
	position: absolute;
	top: 0;
	left: 0;
	background-color: #166aa2;
	width: 76%;
	height: 100%;
	border-radius: 0.25rem;
}




/* https://www.webhek.com/post/css3-animation-sniplet-collection/#/attention_seekers/tada */

.animated {
	-webkit-animation-duration: 1s;
	animation-duration: 1s;
	-webkit-animation-fill-mode: both;
	animation-fill-mode: both;
  }
  .animated.infinite {
	-webkit-animation-iteration-count: infinite;
	animation-iteration-count: infinite;
  }
  .animated.hinge {
	-webkit-animation-duration: 2s;
	animation-duration: 2s;
  }
  /*the animation definition*/
  @-webkit-keyframes tada {
	0% {
	  -webkit-transform: scale3d(1, 1, 1);
	  transform: scale3d(1, 1, 1)
	}
	10%,
	20% {
	  -webkit-transform: scale3d(.9, .9, .9) rotate3d(0, 0, 1, -3deg);
	  transform: scale3d(.9, .9, .9) rotate3d(0, 0, 1, -3deg)
	}
	30%,
	50%,
	70%,
	90% {
	  -webkit-transform: scale3d(1.1, 1.1, 1.1) rotate3d(0, 0, 1, 3deg);
	  transform: scale3d(1.1, 1.1, 1.1) rotate3d(0, 0, 1, 3deg)
	}
	40%,
	60%,
	80% {
	  -webkit-transform: scale3d(1.1, 1.1, 1.1) rotate3d(0, 0, 1, -3deg);
	  transform: scale3d(1.1, 1.1, 1.1) rotate3d(0, 0, 1, -3deg)
	}
	100% {
	  -webkit-transform: scale3d(1, 1, 1);
	  transform: scale3d(1, 1, 1)
	}
  }
  @keyframes tada {
	0% {
	  -webkit-transform: scale3d(1, 1, 1);
	  -ms-transform: scale3d(1, 1, 1);
	  transform: scale3d(1, 1, 1)
	}
	10%,
	20% {
	  -webkit-transform: scale3d(.9, .9, .9) rotate3d(0, 0, 1, -3deg);
	  -ms-transform: scale3d(.9, .9, .9) rotate3d(0, 0, 1, -3deg);
	  transform: scale3d(.9, .9, .9) rotate3d(0, 0, 1, -3deg)
	}
	30%,
	50%,
	70%,
	90% {
	  -webkit-transform: scale3d(1.1, 1.1, 1.1) rotate3d(0, 0, 1, 3deg);
	  -ms-transform: scale3d(1.1, 1.1, 1.1) rotate3d(0, 0, 1, 3deg);
	  transform: scale3d(1.1, 1.1, 1.1) rotate3d(0, 0, 1, 3deg)
	}
	40%,
	60%,
	80% {
	  -webkit-transform: scale3d(1.1, 1.1, 1.1) rotate3d(0, 0, 1, -3deg);
	  -ms-transform: scale3d(1.1, 1.1, 1.1) rotate3d(0, 0, 1, -3deg);
	  transform: scale3d(1.1, 1.1, 1.1) rotate3d(0, 0, 1, -3deg)
	}
	100% {
	  -webkit-transform: scale3d(1, 1, 1);
	  -ms-transform: scale3d(1, 1, 1);
	  transform: scale3d(1, 1, 1)
	}
  }
  .tada {
	-webkit-animation-name: tada;
	animation-name: tada
  }
  


.bd-callout-info {
    --bd-callout-color: var(--bs-info-text);
    --bd-callout-bg: var(--bs-info-bg-subtle);
    --bd-callout-border: var(--bs-info-border-subtle);
}

.bd-callout {
	font-size: 18px;
    --bs-link-color-rgb: var(--bd-callout-link);
    --bs-code-color: var(--bd-callout-code-color);
    padding: 1.25rem;
    margin-top: 1rem;
    margin-bottom: 1rem;
    color: var(--bd-callout-color, inherit);
    background-color: var(--bd-callout-bg, var(--bs-gray-100));
    border-left: 0.25rem solid var(--bd-callout-border, var(--bs-gray-300));
}


.boxed-number {
	border: 2px solid #1b6795; /* 外框的样式，可以根据需要调整颜色、宽度等 */
	padding: 4px 5px; /* 可选，添加一些内边距 */
	display: inline-block; /* 使得边框仅包围内容 */
	color: #1b6795;
}

.boxed-number.up-exp {
	border: 2px solid #951b21; /* 外框的样式，可以根据需要调整颜色、宽度等 */
	padding: 4px 5px; /* 可选，添加一些内边距 */
	display: inline-block; /* 使得边框仅包围内容 */
	color: #951b21;
}

.boxed-number.down-exp {
	border: 2px solid #1b6795; /* 外框的样式，可以根据需要调整颜色、宽度等 */
	padding: 4px 5px; /* 可选，添加一些内边距 */
	display: inline-block; /* 使得边框仅包围内容 */
	color: #1b6795;
}

.boxed-number.dif-exp {
	border: 2px solid #d33b20; /* 外框的样式，可以根据需要调整颜色、宽度等 */
	padding: 4px 5px; /* 可选，添加一些内边距 */
	display: inline-block; /* 使得边框仅包围内容 */
	color: #d33b20;
}

.boxed-number.assco-exp {
	border: 2px solid #eb6206; /* 外框的样式，可以根据需要调整颜色、宽度等 */
	padding: 4px 5px; /* 可选，添加一些内边距 */
	display: inline-block; /* 使得边框仅包围内容 */
	color: #eb6206;
}

.spinner {
	margin: 100px auto;
	height: 60px;
	text-align: center;
	font-size: 10px;
}
   
.spinner > div {
	background-color: #166aa2;
	height: 100%;
	width: 6px;
	display: inline-block;
	-webkit-animation: stretchdelay 1.2s infinite ease-in-out;
	animation: stretchdelay 1.2s infinite ease-in-out;
}

.spinner .rect2 {
	-webkit-animation-delay: -1.1s;
	animation-delay: -1.1s;
}

.spinner .rect3 {
	-webkit-animation-delay: -1.0s;
	animation-delay: -1.0s;
}

.spinner .rect4 {
	-webkit-animation-delay: -0.9s;
	animation-delay: -0.9s;
}

.spinner .rect5 {
	-webkit-animation-delay: -0.8s;
	animation-delay: -0.8s;
}

@-webkit-keyframes stretchdelay {
	0%, 40%, 100% { -webkit-transform: scaleY(0.4) } 
	20% { -webkit-transform: scaleY(1.0) }
}

@keyframes stretchdelay {
	0%, 40%, 100% {
		transform: scaleY(0.4);
		-webkit-transform: scaleY(0.4);
	}  20% {
		transform: scaleY(1.0);
		-webkit-transform: scaleY(1.0);
	}
}