{"id":5,"date":"2020-04-27T02:50:14","date_gmt":"2020-04-27T02:50:14","guid":{"rendered":"http:\/\/biopharm.zju.edu.cn\/coviedb\/?page_id=5"},"modified":"2020-04-27T07:25:30","modified_gmt":"2020-04-27T07:25:30","slug":"home","status":"publish","type":"page","link":"https:\/\/pgx.zju.edu.cn\/coviedb\/","title":{"rendered":"Home"},"content":{"rendered":"\n

We predict all the potential B\/T cell epitopes for 2019-nCoV<\/strong>, RaTG13-CoV<\/strong>, SARS-CoV<\/strong> and MERS-CoV<\/strong> based on the proteins they express for providing potential targets of vaccines that could effective to different coronaviruses. RaTG13-CoV is added because of its high homology with 2019-nCoV (96% whole genome identity). The table below shows the statistcal results of all predicted epitopes.<\/p>\n\n\n\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
Coronavirus<\/th>Protein<\/th>Length<\/th>No. of amino acids
\nfor B-cell epitopes<\/th>		No. of T-cell epitopes
\npresented by HLA I alleles<\/th>		No. of T-cell epitopes
\npresented by HLA II alleles<\/th>\n<\/tr>\n<\/thead>\n
2019-nCoV<\/td>E<\/td>75<\/td>21<\/td>40<\/td>68<\/td>\n<\/tr>\n
2019-nCoV<\/td>M<\/td>222<\/td>70<\/td>125<\/td>333<\/td>\n<\/tr>\n
2019-nCoV<\/td>N<\/td>419<\/td>155<\/td>90<\/td>244<\/td>\n<\/tr>\n
2019-nCoV<\/td>ORF10<\/td>38<\/td>6<\/td>20<\/td>12<\/td>\n<\/tr>\n
2019-nCoV<\/td>ORF1ab<\/td>7096<\/td>1685<\/td>2716<\/td>7868<\/td>\n<\/tr>\n
2019-nCoV<\/td>ORF3a<\/td>275<\/td>96<\/td>118<\/td>438<\/td>\n<\/tr>\n
2019-nCoV<\/td>ORF6<\/td>61<\/td>17<\/td>25<\/td>219<\/td>\n<\/tr>\n
2019-nCoV<\/td>ORF7a<\/td>121<\/td>38<\/td>48<\/td>84<\/td>\n<\/tr>\n
2019-nCoV<\/td>ORF7b<\/td>43<\/td>9<\/td>14<\/td>15<\/td>\n<\/tr>\n
2019-nCoV<\/td>ORF8<\/td>121<\/td>33<\/td>30<\/td>80<\/td>\n<\/tr>\n
2019-nCoV<\/td>S<\/td>1273<\/td>359<\/td>431<\/td>1471<\/td>\n<\/tr>\n
MERS-CoV<\/td>E<\/td>82<\/td>9<\/td>29<\/td>76<\/td>\n<\/tr>\n
MERS-CoV<\/td>M<\/td>219<\/td>43<\/td>134<\/td>246<\/td>\n<\/tr>\n
MERS-CoV<\/td>N<\/td>413<\/td>184<\/td>105<\/td>204<\/td>\n<\/tr>\n
MERS-CoV<\/td>ORF1ab<\/td>7078<\/td>1604<\/td>2722<\/td>8285<\/td>\n<\/tr>\n
MERS-CoV<\/td>ORF3<\/td>103<\/td>39<\/td>35<\/td>59<\/td>\n<\/tr>\n
MERS-CoV<\/td>ORF4a<\/td>109<\/td>41<\/td>42<\/td>31<\/td>\n<\/tr>\n
MERS-CoV<\/td>ORF4b<\/td>246<\/td>52<\/td>116<\/td>392<\/td>\n<\/tr>\n
MERS-CoV<\/td>ORF5<\/td>224<\/td>34<\/td>118<\/td>259<\/td>\n<\/tr>\n
MERS-CoV<\/td>ORF8b<\/td>112<\/td>30<\/td>40<\/td>174<\/td>\n<\/tr>\n
MERS-CoV<\/td>S<\/td>1353<\/td>357<\/td>482<\/td>1804<\/td>\n<\/tr>\n
RaTG13-CoV<\/td>E<\/td>75<\/td>19<\/td>40<\/td>68<\/td>\n<\/tr>\n
RaTG13-CoV<\/td>M<\/td>221<\/td>41<\/td>125<\/td>329<\/td>\n<\/tr>\n
RaTG13-CoV<\/td>N<\/td>419<\/td>191<\/td>86<\/td>238<\/td>\n<\/tr>\n
RaTG13-CoV<\/td>NS3<\/td>275<\/td>83<\/td>114<\/td>467<\/td>\n<\/tr>\n
RaTG13-CoV<\/td>NS6<\/td>61<\/td>14<\/td>25<\/td>219<\/td>\n<\/tr>\n
RaTG13-CoV<\/td>NS7a<\/td>121<\/td>31<\/td>44<\/td>90<\/td>\n<\/tr>\n
RaTG13-CoV<\/td>NS7b<\/td>43<\/td>7<\/td>14<\/td>14<\/td>\n<\/tr>\n
RaTG13-CoV<\/td>NS8<\/td>121<\/td>28<\/td>26<\/td>80<\/td>\n<\/tr>\n
RaTG13-CoV<\/td>ORF1ab<\/td>7095<\/td>1689<\/td>2700<\/td>7695<\/td>\n<\/tr>\n
RaTG13-CoV<\/td>S<\/td>1278<\/td>297<\/td>423<\/td>1621<\/td>\n<\/tr>\n
SARS-CoV<\/td>E<\/td>76<\/td>18<\/td>37<\/td>56<\/td>\n<\/tr>\n
SARS-CoV<\/td>M<\/td>221<\/td>45<\/td>133<\/td>346<\/td>\n<\/tr>\n
SARS-CoV<\/td>ORF1ab<\/td>7073<\/td>1680<\/td>2651<\/td>7758<\/td>\n<\/tr>\n
SARS-CoV<\/td>ORF3a<\/td>274<\/td>88<\/td>95<\/td>435<\/td>\n<\/tr>\n
SARS-CoV<\/td>ORF3b<\/td>154<\/td>29<\/td>81<\/td>307<\/td>\n<\/tr>\n
SARS-CoV<\/td>ORF6<\/td>63<\/td>17<\/td>25<\/td>122<\/td>\n<\/tr>\n
SARS-CoV<\/td>ORF7a<\/td>122<\/td>31<\/td>45<\/td>68<\/td>\n<\/tr>\n
SARS-CoV<\/td>ORF7b<\/td>44<\/td>8<\/td>13<\/td>39<\/td>\n<\/tr>\n
SARS-CoV<\/td>ORF8a<\/td>39<\/td>12<\/td>8<\/td>0<\/td>\n<\/tr>\n
SARS-CoV<\/td>ORF8b<\/td>84<\/td>19<\/td>34<\/td>36<\/td>\n<\/tr>\n
SARS-CoV<\/td>ORF9a<\/td>422<\/td>188<\/td>98<\/td>231<\/td>\n<\/tr>\n
SARS-CoV<\/td>ORF9b<\/td>98<\/td>30<\/td>25<\/td>47<\/td>\n<\/tr>\n
SARS-CoV<\/td>S<\/td>1255<\/td>279<\/td>441<\/td>1564<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n","protected":false},"excerpt":{"rendered":"

We predict all the potential B\/T cell epitopes for 2019-nCoV, RaTG13-CoV, SARS-CoV and MERS-CoV based on the proteins they express…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/pgx.zju.edu.cn\/coviedb\/wp-json\/wp\/v2\/pages\/5"}],"collection":[{"href":"https:\/\/pgx.zju.edu.cn\/coviedb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pgx.zju.edu.cn\/coviedb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pgx.zju.edu.cn\/coviedb\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pgx.zju.edu.cn\/coviedb\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":11,"href":"https:\/\/pgx.zju.edu.cn\/coviedb\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":67,"href":"https:\/\/pgx.zju.edu.cn\/coviedb\/wp-json\/wp\/v2\/pages\/5\/revisions\/67"}],"wp:attachment":[{"href":"https:\/\/pgx.zju.edu.cn\/coviedb\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}