We predict all the potential B/T cell epitopes for 2019-nCoV, RaTG13-CoV, SARS-CoV and MERS-CoV based on the proteins they express for providing potential targets of vaccines that could effective to different coronaviruses. RaTG13-CoV is added because of its high homology with 2019-nCoV (96% whole genome identity). The table below shows the statistcal results of all predicted epitopes.
Coronavirus | Protein | Length | No. of amino acids for B-cell epitopes | No. of T-cell epitopes presented by HLA I alleles | No. of T-cell epitopes presented by HLA II alleles |
---|---|---|---|---|---|
2019-nCoV | E | 75 | 21 | 40 | 68 |
2019-nCoV | M | 222 | 70 | 125 | 333 |
2019-nCoV | N | 419 | 155 | 90 | 244 |
2019-nCoV | ORF10 | 38 | 6 | 20 | 12 |
2019-nCoV | ORF1ab | 7096 | 1685 | 2716 | 7868 |
2019-nCoV | ORF3a | 275 | 96 | 118 | 438 |
2019-nCoV | ORF6 | 61 | 17 | 25 | 219 |
2019-nCoV | ORF7a | 121 | 38 | 48 | 84 |
2019-nCoV | ORF7b | 43 | 9 | 14 | 15 |
2019-nCoV | ORF8 | 121 | 33 | 30 | 80 |
2019-nCoV | S | 1273 | 359 | 431 | 1471 |
MERS-CoV | E | 82 | 9 | 29 | 76 |
MERS-CoV | M | 219 | 43 | 134 | 246 |
MERS-CoV | N | 413 | 184 | 105 | 204 |
MERS-CoV | ORF1ab | 7078 | 1604 | 2722 | 8285 |
MERS-CoV | ORF3 | 103 | 39 | 35 | 59 |
MERS-CoV | ORF4a | 109 | 41 | 42 | 31 |
MERS-CoV | ORF4b | 246 | 52 | 116 | 392 |
MERS-CoV | ORF5 | 224 | 34 | 118 | 259 |
MERS-CoV | ORF8b | 112 | 30 | 40 | 174 |
MERS-CoV | S | 1353 | 357 | 482 | 1804 |
RaTG13-CoV | E | 75 | 19 | 40 | 68 |
RaTG13-CoV | M | 221 | 41 | 125 | 329 |
RaTG13-CoV | N | 419 | 191 | 86 | 238 |
RaTG13-CoV | NS3 | 275 | 83 | 114 | 467 |
RaTG13-CoV | NS6 | 61 | 14 | 25 | 219 |
RaTG13-CoV | NS7a | 121 | 31 | 44 | 90 |
RaTG13-CoV | NS7b | 43 | 7 | 14 | 14 |
RaTG13-CoV | NS8 | 121 | 28 | 26 | 80 |
RaTG13-CoV | ORF1ab | 7095 | 1689 | 2700 | 7695 |
RaTG13-CoV | S | 1278 | 297 | 423 | 1621 |
SARS-CoV | E | 76 | 18 | 37 | 56 |
SARS-CoV | M | 221 | 45 | 133 | 346 |
SARS-CoV | ORF1ab | 7073 | 1680 | 2651 | 7758 |
SARS-CoV | ORF3a | 274 | 88 | 95 | 435 |
SARS-CoV | ORF3b | 154 | 29 | 81 | 307 |
SARS-CoV | ORF6 | 63 | 17 | 25 | 122 |
SARS-CoV | ORF7a | 122 | 31 | 45 | 68 |
SARS-CoV | ORF7b | 44 | 8 | 13 | 39 |
SARS-CoV | ORF8a | 39 | 12 | 8 | 0 |
SARS-CoV | ORF8b | 84 | 19 | 34 | 36 |
SARS-CoV | ORF9a | 422 | 188 | 98 | 231 |
SARS-CoV | ORF9b | 98 | 30 | 25 | 47 |
SARS-CoV | S | 1255 | 279 | 441 | 1564 |